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dc.contributor.authorMcFarland, Amelia J
dc.contributor.authorAnoopkumar-Dukie, Shailendra
dc.contributor.authorArora, Devinder S
dc.contributor.authorGrant, Gary D
dc.contributor.authorMcDermott, Catherine M
dc.contributor.authorPerkins, Anthony V
dc.contributor.authorDavey, Andrew K
dc.date.accessioned2017-07-31T01:30:21Z
dc.date.available2017-07-31T01:30:21Z
dc.date.issued2014
dc.identifier.issn1422-0067
dc.identifier.doi10.3390/ijms151120607
dc.identifier.urihttp://hdl.handle.net/10072/65646
dc.description.abstract3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, commonly referred to as statins, are widely used in the treatment of dyslipidaemia, in addition to providing primary and secondary prevention against cardiovascular disease and stroke. Statins' effects on the central nervous system (CNS), particularly on cognition and neurological disorders such as stroke and multiple sclerosis, have received increasing attention in recent years, both within the scientific community and in the media. Current understanding of statins' effects is limited by a lack of mechanism-based studies, as well as the assumption that all statins have the same pharmacological effect in the central nervous system. This review aims to provide an updated discussion on the molecular mechanisms contributing to statins' possible effects on cognitive function, neurodegenerative disease, and various neurological disorders such as stroke, epilepsy, depression and CNS cancers. Additionally, the pharmacokinetic differences between statins and how these may result in statin-specific neurological effects are also discussed.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent873015 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.publisherMDPI
dc.publisher.placeSwitzerland
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom20607
dc.relation.ispartofpageto20637
dc.relation.ispartofjournalInternational Journal of Molecular Sciences
dc.relation.ispartofvolume15
dc.rights.retentionY
dc.subject.fieldofresearchClinical Pharmacology and Therapeutics
dc.subject.fieldofresearchOther Chemical Sciences
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchOther Biological Sciences
dc.subject.fieldofresearchcode111502
dc.subject.fieldofresearchcode0399
dc.subject.fieldofresearchcode0604
dc.subject.fieldofresearchcode0699
dc.titleMolecular Mechanisms Underlying the Effects of Statins in the Central Nervous System
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/3.0/
gro.facultyGriffith Health, School of Pharmacy
gro.rights.copyright© 2014 by the authors; licensee MDPI, author. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorPerkins, Anthony V.
gro.griffith.authorGrant, Gary D.
gro.griffith.authorMcFarland, Amelia J.
gro.griffith.authorAnoopkumar-Dukie, Shailendra
gro.griffith.authorDavey, Andrew
gro.griffith.authorArora, Devinder S.


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