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dc.contributor.authorJayasinghe, Rohan
dc.contributor.authorCraig, Ian Hamilton
dc.contributor.authorMohan, Raj Kamal Alfred
dc.date.accessioned2015-01-22
dc.date.accessioned2017-03-02T00:52:29Z
dc.date.available2015-02-19T05:56:41Z
dc.date.available2017-03-02T00:52:29Z
dc.date.issued2014
dc.identifier.issn0030-9982
dc.identifier.urihttp://hdl.handle.net/10072/66181
dc.description.abstractLipoprotein (a) is a strong and independent risk factor for atherosclerosis severity and a predictor of the risk of ischaemic heart disease and stroke. Many questions are still unanswered in relation to the clinical relevance of the scientific observations on Lp(a) and its application in the realms of cardiovascular prevention. Lp(a), a lipoprotein subtype, is linked to the Apo(a) gene located on chromosome 6q26-27 independently associated with increased risk of coronary artery disease (CAD). For this review, data sources from Cochrane, Pubmed, MEDLINE from 1960 till 2012 were analysed systematically. At least one-off measurement of plasma Lp(a) was found to be indicated in those with premature coronary disease when no real causative factor was identified. Management seemed promising with PCSK9 I, apheresis, CETPI, dietary choices and ACEi. There was clear evidence that Lp(a) is a definite risk marker for atherosclerotic cardiovascular disease (CVD).
dc.description.peerreviewedNo
dc.description.publicationstatusYes
dc.format.extent230305 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoen_US
dc.publisherPakistan Medical Association
dc.publisher.placePakistan
dc.publisher.urihttp://www.jpma.org.pk/full_article_text.php?article_id=6303
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom447
dc.relation.ispartofpageto450
dc.relation.ispartofissue4
dc.relation.ispartofjournalThe Journal of the Pakistan Medical Association.
dc.relation.ispartofvolume64
dc.rights.retentionY
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode1103
dc.titleLipoprotein (A) in clinical practice
dc.typeJournal article
dc.type.descriptionC2 - Articles (Other)
dc.type.codec2
gro.facultyGriffith Health Faculty
gro.rights.copyright© 2014 Pakistan Medical Association. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2015-02-19T05:56:41Z
gro.hasfulltextFull Text
gro.griffith.authorJayasinghe, Rohan
gro.griffith.authorHamilton-Craig, Ian


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