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dc.contributor.authorSuzuki, Hiroyuki
dc.contributor.authorKido, Teruhiko
dc.contributor.authorOkamoto, Rie
dc.contributor.authorNhu, Dang Duc
dc.contributor.authorNishijo, Muneko
dc.contributor.authorNakagawa, Hideaki
dc.contributor.authorTawara, Kenji
dc.contributor.authorHorikawa, Hiroaki
dc.contributor.authorSato, Yuko
dc.contributor.authorPhung, Dung
dc.contributor.authorThom, Le Hong
dc.contributor.authorHung, Nguyen Ngoc
dc.date.accessioned2017-05-03T15:26:07Z
dc.date.available2017-05-03T15:26:07Z
dc.date.issued2014
dc.identifier.issn14220067
dc.identifier.doi10.3390/ijms15057485
dc.identifier.urihttp://hdl.handle.net/10072/66206
dc.description.abstractThe aim of this study was to clarify the relationship between dioxin concentrations in breast milk and the sister chromatid exchange (SCE) frequency in women from herbicide-sprayed and non sprayed areas. Blood samples were taken from 21 women with high TCDD (tetrachlorodibenzo-p-dioxin) levels from sprayed areas, 23 women with moderate TCDD levels from sprayed areas, and 19 women from non sprayed areas to determine their SCE frequency. The SCE frequencies for the high and moderate TCDD groups from the sprayed area and for the non sprayed area group were 2.40, 2.19, and 1.48 per cell, respectively. Multiple regression analysis showed that the standardized ߠvalues for 1,2,3,6,7,8-hexaCDD (ߠ= 0.60), 1,2,3,4,6,7,8-heptaCDD (ߠ= 0.64), and octaCDD (ߠ= 0.65) were higher than those for TCDD (ߠ= 0.34) and 1,2,3,7,8-pentaCDD (ߠ= 0.42). The adjusted R2 value for polyCDDs (R2 = 0.38) was higher than that for polyCDD toxic equivalents (TEQ (toxic equivalents); R2 = 0.23). This study therefore shows that levels of hexa-, hepta-, and octaCDD, which were previously regarded as being less toxic than TCDD, are closely related to SCE frequency and that the level of dioxin (pg/g lipid) is potentially more useful as an indicator than TEQ value for explaining SCE frequency.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent246711 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherM D P I AG
dc.publisher.placeSwitzerland
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom7485
dc.relation.ispartofpageto7499
dc.relation.ispartofissue5
dc.relation.ispartofjournalInternational Journal of Molecular Science
dc.relation.ispartofvolume15
dc.rights.retentionY
dc.subject.fieldofresearchChemical Sciences not elsewhere classified
dc.subject.fieldofresearchGenetics not elsewhere classified
dc.subject.fieldofresearchBiological Sciences not elsewhere classified
dc.subject.fieldofresearchOther Chemical Sciences
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchOther Biological Sciences
dc.subject.fieldofresearchcode039999
dc.subject.fieldofresearchcode060499
dc.subject.fieldofresearchcode069999
dc.subject.fieldofresearchcode0399
dc.subject.fieldofresearchcode0604
dc.subject.fieldofresearchcode0699
dc.titleThe Relationship between Dioxin Congeners in the Breast Milk of Vietnamese Women and Sister Chromatid Exchange
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/3.0/
gro.rights.copyright© 2014 by the authors; licensee MDPI, author. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorPhung, Dung T.


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