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  • Towards human on a chip: recent progress and future perspective

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    101020_1.pdf (1.236Mb)
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    Accepted Manuscript (AM)
    Author(s)
    Van Noort, D
    Park, S
    Nguyen, NT
    Griffith University Author(s)
    Nguyen, Nam-Trung
    Year published
    2014
    Metadata
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    Abstract
    A system of multiple organs integrated on a single chip or human on a chip (HUC) has a great potential for drug discovery. Such a system helps to advance the fundamental understanding of diseases as well as the complex interac- tions between cells, tissues and organs. HUC models will potentially overcome the shortcomings of traditional animal models such as high cost, incompatibility with human physiology, the inability to control and manipulate the microenvi- ronment in vivo and the lack of efficacy. The matching length scale of biological structures and micromachined compo- nents makes a microfluidic chip the ideal platform ...
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    A system of multiple organs integrated on a single chip or human on a chip (HUC) has a great potential for drug discovery. Such a system helps to advance the fundamental understanding of diseases as well as the complex interac- tions between cells, tissues and organs. HUC models will potentially overcome the shortcomings of traditional animal models such as high cost, incompatibility with human physiology, the inability to control and manipulate the microenvi- ronment in vivo and the lack of efficacy. The matching length scale of biological structures and micromachined compo- nents makes a microfluidic chip the ideal platform to investigate physiological events. This paper presents an overview of the state of the art of the development of HUC. The paper also provides a perspective on the integration of cell culture on a chip to create an ethical human model and to provide insights into the sensitivity of different cell constructs on drugs.
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    Journal Title
    Micro and Nanosystems
    Volume
    6
    Issue
    4
    Publisher URI
    http://benthamscience.com/journal/abstracts.php?journalID=mns&articleID=128951
    Copyright Statement
    © 2014 Bentham Science Publishers. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
    Subject
    Systems biology
    Biomechanical engineering
    Publication URI
    http://hdl.handle.net/10072/66606
    Collection
    • Journal articles

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