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dc.contributor.authorYoulden, Danny R
dc.contributor.authorYoul, Philippa H
dc.contributor.authorSoyer, H Peter
dc.contributor.authorFritschi, Lin
dc.contributor.authorBaade, Peter D
dc.date.accessioned2017-05-03T15:24:00Z
dc.date.available2017-05-03T15:24:00Z
dc.date.issued2014
dc.identifier.issn0022-202X
dc.identifier.doi10.1038/jid.2014.266
dc.identifier.urihttp://hdl.handle.net/10072/66624
dc.description.abstractThe relatively high incidence of Merkel cell carcinoma (MCC) in Queensland provides a valuable opportunity to examine links with other cancers. A retrospective cohort study was performed using data from the Queensland Cancer Registry. Standardized incidence ratios (SIRs) were used to approximate the relative risk of being diagnosed with another primary cancer either following or prior to MCC. Patients with an eligible first primary MCC (n=787) had more than double the expected number of subsequent primary cancers (SIR=2.19, 95% confidence interval (CI)=1.84-2.60; P<0.001). Conversely, people who were initially diagnosed with cancers other than MCC were about two and a half times more likely to have a subsequent primary MCC (n=244) compared with the general population (SIR=2.69, 95% CI=2.36-3.05; P<0.001). Significantly increased bi-directional relative risks were found for melanoma, lip cancer, head and neck cancer, lung cancer, myelodysplastic diseases, and cancer with unknown primary site. In addition, risks were elevated for female breast cancer and kidney cancer following a first primary MCC, and for subsequent MCCs following first primary colorectal cancer, prostate cancer, non-Hodgkin lymphoma, or lymphoid leukemia. These results suggest that several shared pathways are likely for MCC and other cancers, including immunosuppression, UV radiation, and genetics.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent153643 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom2883
dc.relation.ispartofpageto2889
dc.relation.ispartofjournalThe Journal of Investigative Dermatology
dc.relation.ispartofvolume134
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchOncology and carcinogenesis not elsewhere classified
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3211
dc.subject.fieldofresearchcode321199
dc.titleMultiple Primary Cancers Associated with Merkel Cell Carcinoma in Queensland, Australia, 1982-2011
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2014 Nature Publishing Group. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorYoul, Philippa
gro.griffith.authorBaade, Peter D.
gro.griffith.authorYoulden, Danny R.


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