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  • Inflammation and cancer stem cells

    Author(s)
    Shigdar, Sarah
    Li, Yong
    Bhattacharya, Santanu
    O'Connor, Michael
    Pu, Chunwen
    Lin, Jia
    Wang, Tao
    Xiang, Dongxi
    Kong, Lingxue
    Wei, Ming Q
    Zhu, Yimin
    Zhou, Shufeng
    Duan, Wei
    Griffith University Author(s)
    Wei, Ming Q.
    Lin, Jack
    Year published
    2014
    Metadata
    Show full item record
    Abstract
    Cancer stem cells are becoming recognised as being responsible for metastasis and treatment resistance. The complex cellular and molecular network that regulates cancer stem cells and the role that inflammation plays in cancer progression are slowly being elucidated. Cytokines, secreted by tumour associated immune cells, activate the necessary pathways required by cancer stem cells to facilitate cancer stem cells progressing through the epithelial-mesenchymal transition and migrating to distant sites. Once in situ, these cancer stem cells can secrete their own attractants, thus providing an environment whereby these cells ...
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    Cancer stem cells are becoming recognised as being responsible for metastasis and treatment resistance. The complex cellular and molecular network that regulates cancer stem cells and the role that inflammation plays in cancer progression are slowly being elucidated. Cytokines, secreted by tumour associated immune cells, activate the necessary pathways required by cancer stem cells to facilitate cancer stem cells progressing through the epithelial-mesenchymal transition and migrating to distant sites. Once in situ, these cancer stem cells can secrete their own attractants, thus providing an environment whereby these cells can continue to propagate the tumour in a secondary niche.
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    Journal Title
    Cancer Letters
    Volume
    345
    Issue
    2
    DOI
    https://doi.org/10.1016/j.canlet.2013.07.031
    Subject
    Medical and Health Sciences not elsewhere classified
    Oncology and Carcinogenesis
    Publication URI
    http://hdl.handle.net/10072/66633
    Collection
    • Journal articles

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