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  • Potent cytotoxic peptides from the Australian marine sponge Pipestela candelabra

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    Author
    Tran, Trong
    Pham, Ngoc
    Fechner, Gregory
    Hooper, John
    Quinn, Ronald
    Year published
    2014
    Metadata
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    Abstract
    Two consecutive prefractionated fractions of the Australian marine sponge extract, Pipestela candelabra, were identified to be selectively active on the human prostate cancer cells (PC3) compared to the human neonatal foreskin fibroblast non-cancer cells (NFF). Twelve secondary metabolites were isolated in which four compounds are new small peptides. Their structures were characterized by spectroscopic and chemical analysis. These compounds inhibited selectively the growth of prostate cancer cells with IC50 values in the picomolar to sub-micromolar range. Structure-activity relationship of these compounds is discussed.Two consecutive prefractionated fractions of the Australian marine sponge extract, Pipestela candelabra, were identified to be selectively active on the human prostate cancer cells (PC3) compared to the human neonatal foreskin fibroblast non-cancer cells (NFF). Twelve secondary metabolites were isolated in which four compounds are new small peptides. Their structures were characterized by spectroscopic and chemical analysis. These compounds inhibited selectively the growth of prostate cancer cells with IC50 values in the picomolar to sub-micromolar range. Structure-activity relationship of these compounds is discussed.
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    Journal Title
    Marine Drugs
    Volume
    12
    DOI
    https://doi.org/10.3390/md12063399
    Copyright Statement
    © 2014 by the authors; licensee MDPI, author. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Medicinal and Biomolecular Chemistry not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/66665
    Collection
    • Journal articles

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