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  • Cardiovascular Effects of Drugs Used to Treat Alzheimer's Disease

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    Author(s)
    Howes, Laurence Guy
    Griffith University Author(s)
    Howes, Laurence G.
    Year published
    2014
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    Abstract
    Drugs that are used to treat Alzheimer's disease include the acetyl cholinesterase inhibitors (ACHIs) donepezil, rivastigmine and galantamine and the NMDA receptor antagonist memantine. Adverse cardiovascular events with these drugs are very uncommon. However, there is evidence that ACHI therapy is associated with a small but significant increase in the risk of syncope and bradycardia. There are also a few reports that these drugs may occasionally be associated with QT prolongation and torsades de pointes ventricular tachycardia. Adverse cardiovascular effects of ACHIs including syncope and bradycardia are less common than ...
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    Drugs that are used to treat Alzheimer's disease include the acetyl cholinesterase inhibitors (ACHIs) donepezil, rivastigmine and galantamine and the NMDA receptor antagonist memantine. Adverse cardiovascular events with these drugs are very uncommon. However, there is evidence that ACHI therapy is associated with a small but significant increase in the risk of syncope and bradycardia. There are also a few reports that these drugs may occasionally be associated with QT prolongation and torsades de pointes ventricular tachycardia. Adverse cardiovascular effects of ACHIs including syncope and bradycardia are less common than their adverse gastrointestinal effects, but they remain important considerations in susceptible individuals. In contrast, animal studies and some observational studies suggest that ACHIs may reduce myocardial infarction and cardiovascular mortality and have favourable effects on hemodynamics and survival in heart failure. Further research is required to confirm these potential beneficial effects. Little is known about the cardiovascular effects of memantine but there have been reports of bradycardia and reduced cardiovascular survival associated with its use.
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    Journal Title
    Drug Safety
    Volume
    37
    Issue
    6
    DOI
    https://doi.org/10.1007/s40264-014-0161-z
    Copyright Statement
    © 2014 Her Majesty the Queen in Right of Australia. This is an electronic version of an article published in Drug Safety, Volume 37, Issue 6, pp 391–395, 2014. Drug Safety is available online at: http://link.springer.com/ with the open URL of your article.
    Subject
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/66701
    Collection
    • Journal articles

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