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  • MicroRNAs in the Intracellular Space, Regulation of Organelle Specific Pathways in Health and Disease

    Author(s)
    Nguyen, TT
    Brenu, EW
    Staines, DR
    Marshall-Gradisnik, SM
    Griffith University Author(s)
    Staines, Donald R.
    Marshall-Gradisnik, Sonya M.
    Year published
    2014
    Metadata
    Show full item record
    Abstract
    MicroRNAs (miRNA) are small (~22 nucleotide] non-coding RNA molecules originally characterised as nonsense or junk DNA. Emerging research suggests that these molecules have diverse regulatory roles in an array of molecular, cellular and physiological processes. MiRNAs are versatile and highly stable molecules, therefore, they are able to exist as intracellular or extracellular miRNAs. The purpose of this paper is to review the function and role of miRNAs in the intracellular space with specific focus on the interactions between miRNAs and organelles such as the mitochondria and the rough endoplasmic reticulum. Understanding ...
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    MicroRNAs (miRNA) are small (~22 nucleotide] non-coding RNA molecules originally characterised as nonsense or junk DNA. Emerging research suggests that these molecules have diverse regulatory roles in an array of molecular, cellular and physiological processes. MiRNAs are versatile and highly stable molecules, therefore, they are able to exist as intracellular or extracellular miRNAs. The purpose of this paper is to review the function and role of miRNAs in the intracellular space with specific focus on the interactions between miRNAs and organelles such as the mitochondria and the rough endoplasmic reticulum. Understanding the role of miRNAs in the intracellular space may be vital in understanding the mechanism of certain diseases.
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    Journal Title
    MicroRNA
    Volume
    3
    Issue
    2
    DOI
    https://doi.org/10.2174/2211536604666141218154252
    Subject
    Cellular immunology
    Publication URI
    http://hdl.handle.net/10072/66761
    Collection
    • Journal articles

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