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  • Estrogen receptor alpha gene expression in breast cancer tissues from the Iranian population - a pilot study

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    Author(s)
    Hosseini, Arezoo
    Gopalan, Vinod
    Nassiri, Mohammadreza
    Ghaffarzadehgan, Kamran
    Aslaminejad, Ali
    Ghovvati, Shahrokh
    Smith, Robert A
    Lam, Alfred KY
    Griffith University Author(s)
    Smith, Robert A.
    Lam, Alfred K.
    Gopalan, Vinod
    Nassiri, Mohammad R.
    Year published
    2014
    Metadata
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    Abstract
    Estrogen receptor alpha (ERa) is one of the major sub-types of estrogen receptors. ERa plays an important role in cellular proliferation and differentiation, chiefly in mammary tissues. In the present study we aimed to quantify of ERa mRNA and protein expression in breast tissues from the Iranian population using a real-time PCR assay. Twenty nine breast tissues including 19 adenocarcinomas and 10 normal controls were recruited from the Iranian population. mRNA extraction and cDNA synthesis were performed from these tissues using commercial kits. ERa mRNA and protein expression was quantified using real-time PCR and ...
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    Estrogen receptor alpha (ERa) is one of the major sub-types of estrogen receptors. ERa plays an important role in cellular proliferation and differentiation, chiefly in mammary tissues. In the present study we aimed to quantify of ERa mRNA and protein expression in breast tissues from the Iranian population using a real-time PCR assay. Twenty nine breast tissues including 19 adenocarcinomas and 10 normal controls were recruited from the Iranian population. mRNA extraction and cDNA synthesis were performed from these tissues using commercial kits. ERa mRNA and protein expression was quantified using real-time PCR and immunohistochemistry respectively. The results showed high expression of ERa mRNA (68%) and protein (53%) in the majority of breast cancer tissues compared to normal breast tissues (p= 0.035). Also, high ERa mRNA was associated with tumour size of breast carcinomas. In this study, we first reported the expression of ERa in Iranian patients with breast cancers and demonstrated prevalence of the expression to be similar to breast cancers noted in other populations.
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    Journal Title
    Asian Pacific Journal of Cancer Prevention
    Volume
    15
    Issue
    20
    DOI
    https://doi.org/10.7314/APJCP.2014.15.20.8789
    Copyright Statement
    © The Author(s) 2014. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this journal please refer to the journal’s website or contact the authors.
    Subject
    Clinical sciences
    Oncology and carcinogenesis
    Publication URI
    http://hdl.handle.net/10072/66764
    Collection
    • Journal articles

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