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dc.contributor.authorPaliwal, Kuldip K
dc.contributor.authorSharma, Alok
dc.contributor.authorLyons, James
dc.contributor.authorDehzangi, Abdollah
dc.date.accessioned2017-05-03T15:57:45Z
dc.date.available2017-05-03T15:57:45Z
dc.date.issued2014
dc.identifier.issn1471-2105
dc.identifier.doi10.1186/1471-2105-15-S16-S12
dc.identifier.urihttp://hdl.handle.net/10072/66805
dc.description.abstractDeciphering three dimensional structure of a protein sequence is a challenging task in biological science. Protein fold recognition and protein secondary structure prediction are transitional steps in identifying the three dimensional structure of a protein. For protein fold recognition, evolutionary-based information of amino acid sequences from the position specific scoring matrix (PSSM) has been recently applied with improved results. On the other hand, the SPINE-X predictor has been developed and applied for protein secondary structure prediction. Several reported methods for protein fold recognition have only limited accuracy. In this paper, we have developed a strategy of combining evolutionary-based information (from PSSM) and predicted secondary structure using SPINE-X to improve protein fold recognition. The strategy is based on finding the probabilities of amino acid pairs (AAP). The proposed method has been tested on several protein benchmark datasets and an improvement of 8.9% recognition accuracy has been achieved. We have achieved, for the first time over 90% and 75% prediction accuracies for sequence similarity values below 40% and 25%, respectively. We also obtain 90.6% and 77.0% prediction accuracies, respectively, for the Extended Ding and Dubchak and Taguchi and Gromiha benchmark protein fold recognition datasets widely used for in the literature.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent750682 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefromS12-1
dc.relation.ispartofpagetoS12-9
dc.relation.ispartofissueSuppl 16
dc.relation.ispartofjournalBMC Bioinformatics
dc.relation.ispartofvolume15
dc.rights.retentionY
dc.subject.fieldofresearchMathematical sciences
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchInformation and computing sciences
dc.subject.fieldofresearchcode49
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode46
dc.titleImproving protein fold recognition using the amalgamation of evolutionary-based and structural based information
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0
gro.facultyGriffith Sciences, Griffith School of Engineering
gro.rights.copyright© 2014 Paliwal et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
gro.hasfulltextFull Text
gro.griffith.authorPaliwal, Kuldip K.


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