Absence of an important vaccine and diagnostic target in carriage and disease-related nontypable Haemophilus influenzae

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Author(s)
Smith-Vaughan, Heidi C
Chang, Anne B
Sarovich, Derek S
Marsh, Robyn L
Grimwood, Keith
Leach, Amanda J
Morris, Peter S
Price, Erin P
Griffith University Author(s)
Year published
2014
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Abstract
Nontypeable Haemophilus influenzae (NTHi)-associated disease is a major health problem globally. Whole-genome sequence analysis identified the absence of hpd genes encoding Haemophilus protein D in 3 of 16 phylogenetically distinct NTHi isolates. This novel finding is of potential clinical significance, as protein D and hpd represent important NTHi vaccine antigen and diagnostic targets, respectively.
Journal Title
Clinical and Vaccine Immunology
Volume
21
Issue
2
DOI
Copyright Statement
© 2014 American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Subject
Immunology
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