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  • Absence of an important vaccine and diagnostic target in carriage and disease-related nontypable Haemophilus influenzae

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    Author(s)
    Smith-Vaughan, Heidi C
    Chang, Anne B
    Sarovich, Derek S
    Marsh, Robyn L
    Grimwood, Keith
    Leach, Amanda J
    Morris, Peter S
    Price, Erin P
    Griffith University Author(s)
    Grimwood, Keith
    Year published
    2014
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    Abstract
    Nontypeable Haemophilus influenzae (NTHi)-associated disease is a major health problem globally. Whole-genome sequence analysis identified the absence of hpd genes encoding Haemophilus protein D in 3 of 16 phylogenetically distinct NTHi isolates. This novel finding is of potential clinical significance, as protein D and hpd represent important NTHi vaccine antigen and diagnostic targets, respectively.Nontypeable Haemophilus influenzae (NTHi)-associated disease is a major health problem globally. Whole-genome sequence analysis identified the absence of hpd genes encoding Haemophilus protein D in 3 of 16 phylogenetically distinct NTHi isolates. This novel finding is of potential clinical significance, as protein D and hpd represent important NTHi vaccine antigen and diagnostic targets, respectively.
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    Journal Title
    Clinical and Vaccine Immunology
    Volume
    21
    Issue
    2
    DOI
    https://doi.org/10.1128/CVI.00632-13
    Copyright Statement
    © 2014 American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Immunology
    Publication URI
    http://hdl.handle.net/10072/66806
    Collection
    • Journal articles

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