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dc.contributor.authorWang, Ya
dc.contributor.authorYang, Tian-xiao
dc.contributor.authorSu, Li
dc.contributor.authorYan, Chao
dc.contributor.authorWang, Yi
dc.contributor.authorHuang, Jia
dc.contributor.authorFan, Ming-xia
dc.contributor.authorYin, Da-zi
dc.contributor.authorJin, Zhen
dc.contributor.authorZeng, Ya-wei
dc.contributor.authorShum, David HK
dc.contributor.authorGur, Ruben C
dc.contributor.authorChan, Raymond CK
dc.date.accessioned2017-05-03T11:56:17Z
dc.date.available2017-05-03T11:56:17Z
dc.date.issued2014
dc.identifier.issn0894-4105
dc.identifier.doi10.1037/neu0000035
dc.identifier.urihttp://hdl.handle.net/10072/66823
dc.description.abstractObjective: Prospective memory (PM) refers to the ability to remember to perform actions in the future. Schizophrenia spectrum disorders show impairments in PM but neural correlates of these impairments remain unclear. The present study aimed to examine brain activation during PM to identify impairments in individuals with schizotypal personality features. Method: Nineteen participants with schizotypal features and 22 healthy controls participated in a functional MRI experiment while performing a PM task. Results: Results showed that the prefrontal cortex (including Brodmann Area [BA] 10), middle temporal gyrus, and precuneus were activated when performing the PM task compared with baseline. The schizotypal and control groups did not differ in behavioral PM performance. However, participants with schizotypal features showed decreased activations in the inferior and medial frontal lobes (BA 45, and 8). Conclusions: These results confirmed that the PM network involves prefrontal cortex, including BA 10. The lower activation in prefrontal cortex of individuals with schizotypal features when performing a PM task indicates brain activation abnormality. Notably, this abnormality may occur in the absence of any behavioral manifestation. Our findings support the hypothesis of frontal lobe involvement in PM deficits observed in individuals with schizotypal features.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Psychological Association
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom373
dc.relation.ispartofpageto381
dc.relation.ispartofissue3
dc.relation.ispartofjournalNeuropsychology
dc.relation.ispartofvolume28
dc.rights.retentionY
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode5204
dc.titleNeural correlates of prospective memory in individuals with schizotypal personality features
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorShum, David
gro.griffith.authorChan, Raymond


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