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  • Circulating bilirubin and defense against kidney disease and cardiovascular mortality: mechanisms contributing to protection in clinical investigations

    Author(s)
    Boon, Ai-Ching
    Bulmer, Andrew C
    Coombes, Jeff S
    Fassett, Robert G
    Griffith University Author(s)
    Bulmer, Andrew C.
    Boon, Connie
    Year published
    2014
    Metadata
    Show full item record
    Abstract
    Unconjugated bilirubin is an endogenous circulating antioxidant, bound to albumin, and therefore is retained in the vascular compartment. Bilirubin has well-documented neurotoxic effects in infants; however, current evidence indicates mildly elevated bilirubin is associated with protection from cardiovascular disease and all-cause mortality in adults. Recent clinical studies show mildly elevated bilirubin is associated with protection from kidney damage and dysfunction, in addition to cardiovascular events and all-cause mortality in patients undergoing hemodialysis. This is the first review to examine the clinical evidence ...
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    Unconjugated bilirubin is an endogenous circulating antioxidant, bound to albumin, and therefore is retained in the vascular compartment. Bilirubin has well-documented neurotoxic effects in infants; however, current evidence indicates mildly elevated bilirubin is associated with protection from cardiovascular disease and all-cause mortality in adults. Recent clinical studies show mildly elevated bilirubin is associated with protection from kidney damage and dysfunction, in addition to cardiovascular events and all-cause mortality in patients undergoing hemodialysis. This is the first review to examine the clinical evidence and summarize the potential mechanisms of action that link bilirubin to protection from kidney damage, subsequent kidney failure, and dialysis-related mortality. With this understanding, it is hoped that new therapies will be developed to prevent renal dysfunction and mortality from cardiovascular disease in at-risk individuals
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    Journal Title
    American Journal of Physiology - Renal Physiol
    Volume
    307
    Issue
    2
    DOI
    https://doi.org/10.1152/ajprenal.00039.2014
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
    Subject
    Animal Physiology - Systems
    Cardiology (incl. Cardiovascular Diseases)
    Physiology
    Clinical Sciences
    Medical Physiology
    Publication URI
    http://hdl.handle.net/10072/66839
    Collection
    • Journal articles

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