dc.contributor.author | Boon, Ai-Ching | |
dc.contributor.author | Bulmer, Andrew C | |
dc.contributor.author | Coombes, Jeff S | |
dc.contributor.author | Fassett, Robert G | |
dc.date.accessioned | 2017-05-03T15:40:12Z | |
dc.date.available | 2017-05-03T15:40:12Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1931-857X | |
dc.identifier.doi | 10.1152/ajprenal.00039.2014 | |
dc.identifier.uri | http://hdl.handle.net/10072/66839 | |
dc.description.abstract | Unconjugated bilirubin is an endogenous circulating antioxidant, bound to albumin, and therefore is retained in the vascular compartment. Bilirubin has well-documented neurotoxic effects in infants; however, current evidence indicates mildly elevated bilirubin is associated with protection from cardiovascular disease and all-cause mortality in adults. Recent clinical studies show mildly elevated bilirubin is associated with protection from kidney damage and dysfunction, in addition to cardiovascular events and all-cause mortality in patients undergoing hemodialysis. This is the first review to examine the clinical evidence and summarize the potential mechanisms of action that link bilirubin to protection from kidney damage, subsequent kidney failure, and dialysis-related mortality. With this understanding, it is hoped that new therapies will be developed to prevent renal dysfunction and mortality from cardiovascular disease in at-risk individuals | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Physiological Society | |
dc.publisher.place | United States | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | F123 | |
dc.relation.ispartofpageto | F136 | |
dc.relation.ispartofissue | 2 | |
dc.relation.ispartofjournal | American Journal of Physiology - Renal Physiol | |
dc.relation.ispartofvolume | 307 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Zoology | |
dc.subject.fieldofresearch | Animal physiology - systems | |
dc.subject.fieldofresearch | Cardiology (incl. cardiovascular diseases) | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearch | Medical physiology | |
dc.subject.fieldofresearchcode | 3109 | |
dc.subject.fieldofresearchcode | 310910 | |
dc.subject.fieldofresearchcode | 320101 | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.fieldofresearchcode | 3208 | |
dc.title | Circulating bilirubin and defense against kidney disease and cardiovascular mortality: mechanisms contributing to protection in clinical investigations | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Griffith Health, School of Medical Science | |
gro.rights.copyright | Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information. | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Bulmer, Andrew C. | |