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dc.contributor.authorBoon, Ai-Ching
dc.contributor.authorBulmer, Andrew C
dc.contributor.authorCoombes, Jeff S
dc.contributor.authorFassett, Robert G
dc.date.accessioned2017-05-03T15:40:12Z
dc.date.available2017-05-03T15:40:12Z
dc.date.issued2014
dc.identifier.issn1931-857X
dc.identifier.doi10.1152/ajprenal.00039.2014
dc.identifier.urihttp://hdl.handle.net/10072/66839
dc.description.abstractUnconjugated bilirubin is an endogenous circulating antioxidant, bound to albumin, and therefore is retained in the vascular compartment. Bilirubin has well-documented neurotoxic effects in infants; however, current evidence indicates mildly elevated bilirubin is associated with protection from cardiovascular disease and all-cause mortality in adults. Recent clinical studies show mildly elevated bilirubin is associated with protection from kidney damage and dysfunction, in addition to cardiovascular events and all-cause mortality in patients undergoing hemodialysis. This is the first review to examine the clinical evidence and summarize the potential mechanisms of action that link bilirubin to protection from kidney damage, subsequent kidney failure, and dialysis-related mortality. With this understanding, it is hoped that new therapies will be developed to prevent renal dysfunction and mortality from cardiovascular disease in at-risk individuals
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Physiological Society
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefromF123
dc.relation.ispartofpagetoF136
dc.relation.ispartofissue2
dc.relation.ispartofjournalAmerican Journal of Physiology - Renal Physiol
dc.relation.ispartofvolume307
dc.rights.retentionY
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchAnimal physiology - systems
dc.subject.fieldofresearchCardiology (incl. cardiovascular diseases)
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode310910
dc.subject.fieldofresearchcode320101
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3208
dc.titleCirculating bilirubin and defense against kidney disease and cardiovascular mortality: mechanisms contributing to protection in clinical investigations
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
gro.hasfulltextNo Full Text
gro.griffith.authorBulmer, Andrew C.


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