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dc.contributor.authorGoyal, Vikasen_US
dc.contributor.authorGrimwood, Keithen_US
dc.contributor.authorMarchant, Julieen_US
dc.contributor.authorMasters, Ian Brenten_US
dc.contributor.authorChang, Anne B.en_US
dc.date.accessioned2017-05-03T14:18:04Z
dc.date.available2017-05-03T14:18:04Z
dc.date.issued2014en_US
dc.identifier.issn00039888en_US
dc.identifier.doi10.1136/archdischild-2013-304793en_US
dc.identifier.urihttp://hdl.handle.net/10072/66840
dc.description.abstractAim To determine whether a child with chronic wet cough and poor response to at least 4 weeks of oral antibiotics is more likely to have bronchiectasis. Methods All chest multi-detector computerised tomography (MDCT) scans at a single paediatric tertiary hospital from April 2010 to August 2012 were reviewed retrospectively so as to identify those ordered by respiratory physicians for assessment of children with a chronic wet cough. Information regarding age, sex, ethnicity, indication for imaging and the response to at least 4 weeks of antibiotics before having the scan were recorded from their charts. The data were analysed using simple and multiple logistic regression. Results Of the 144 (87 males) eligible children, 106 (65 males, 30 Indigenous) aged 10-199 months had MDCT scan evidence of bronchiectasis. Antibiotic data were available for 129 children. Among the 105 children with persistent cough despite at least 4 weeks of antibiotics, 88 (83.8%) had bronchiectasis, while of the 24 children whose cough resolved after antibiotics, only six (25.0%) received this diagnosis (adjusted OR 20.9; 95% CI 5.36 to 81.8). Being Indigenous was also independently associated with radiographic evidence of bronchiectasis (adjusted OR 5.86; 95% CI 1.20 to 28.5). Conclusions Further investigations including a MDCT scan should be considered in a child with a chronic wet cough that persists following 4 weeks of oral antibiotics. However, while reducing the likelihood of underlying bronchiectasis, responding well to a single prolonged course of antibiotics does not exclude this diagnosis completely.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent164365 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.publisherB M J Groupen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom522en_US
dc.relation.ispartofpageto525en_US
dc.relation.ispartofjournalArchives of Disease in Childhooden_US
dc.relation.ispartofvolume99en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode119999en_US
dc.titleDoes failed chronic wet cough response to antibiotics predict bronchiectasis?en_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyright© The Author(s) 2014. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this journal please refer to the journal’s website or contact the authors.en_US
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