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dc.contributor.authorNewman, Jeremy RB
dc.contributor.authorBoyle, Richard S
dc.contributor.authorO'Sullivan, John D
dc.contributor.authorSilburn, Peter A
dc.contributor.authorMellick, George D
dc.date.accessioned2017-05-03T14:10:34Z
dc.date.available2017-05-03T14:10:34Z
dc.date.issued2014
dc.identifier.issn0967-5868
dc.identifier.doi10.1016/j.jocn.2014.03.032
dc.identifier.urihttp://hdl.handle.net/10072/66921
dc.description.abstractIt is currently hypothesised that a combination of genetic and environmental factors underlies the development of idiopathic isolated dystonia (IID). In this study, we examined several possible environmental or other non-genetic factors that may influence the risk for IID in Queensland, Australia. We surveyed several environmental exposures, lifestyle factors, medical and family histories to investigate potential risk factors for IID. Associations between putative risk factors and IID were assessed using a total of 184 dystonia patients and 1048 neurologically-normal control subjects sampled from Queensland between 2005 and 2012. Our analyses revealed that anxiety disorders, depression, tremor, cigarette smoking and head injuries with a loss of consciousness were associated with increased risk for IID (p < 0.05), all of which remained statistically significant following an adjustment for multiple hypothesis testing except for depression. We also observed that the risk for dystonia increased with higher cigarette smoking pack-year quartiles in our analyses. Our results suggest possible environmental factors that influence the development of IID and complement the findings of similar dystonia risk factor studies. Further investigation defining the environmental and other non-genetic risk factors for IID may provide insight into the development of the disorder in genetically-susceptible individuals.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherChurchill Livingstone
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom2145
dc.relation.ispartofpageto2149
dc.relation.ispartofissue12
dc.relation.ispartofjournalJournal of Clinical Neuroscience
dc.relation.ispartofvolume21
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchNeurology and neuromuscular diseases
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode320905
dc.titleRisk factors for idiopathic dystonia in Queensland, Australia
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorMellick, George


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