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  • Mitochondrial Complex II in Cancer

    Author(s)
    Kluckova, Katarina
    Neuzil, Jiri
    Rohlena, Jakub
    Griffith University Author(s)
    Neuzil, Jiri
    Year published
    2014
    Metadata
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    Abstract
    Mitochondria have emerged recently as a novel, intriguing target for anti-caner drugs, owing largely to their importance for proper growth of cancer cells. Destabilization of mitochondria often results in the induction of apoptosis in cancer cells that, consequently, may translate into suppression of tumour growth. A class of mitochondria-targeting compounds, mitocans, comprises several groups of agents with different targets within the mitochondrion. Of these, vitamin E analogues have been recently promoted as agents that disrupt mitochondria by several modes of action. These compounds hold substantial promise as potential ...
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    Mitochondria have emerged recently as a novel, intriguing target for anti-caner drugs, owing largely to their importance for proper growth of cancer cells. Destabilization of mitochondria often results in the induction of apoptosis in cancer cells that, consequently, may translate into suppression of tumour growth. A class of mitochondria-targeting compounds, mitocans, comprises several groups of agents with different targets within the mitochondrion. Of these, vitamin E analogues have been recently promoted as agents that disrupt mitochondria by several modes of action. These compounds hold substantial promise as potential anti-cancer drugs of clinical relevance.
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    Book Title
    Mitochondria: The Anti-cancer Target for the Third Millenium
    Publisher URI
    http://dx.doi.org/10.1007/978-94-017-8984-4
    DOI
    https://doi.org/10.1007/978-94-017-8984-4_4
    Subject
    Cancer cell biology
    Publication URI
    http://hdl.handle.net/10072/67089
    Collection
    • Book chapters

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