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dc.contributor.authorKluckova, Katarina
dc.contributor.authorNeuzil, Jiri
dc.contributor.authorRohlena, Jakub
dc.contributor.editorJ. Neuzil, S. Pervaiz and S. Fulda
dc.date.accessioned2017-11-08T12:00:31Z
dc.date.available2017-11-08T12:00:31Z
dc.date.issued2014
dc.identifier.isbn9789401789844
dc.identifier.doi10.1007/978-94-017-8984-4_4
dc.identifier.urihttp://hdl.handle.net/10072/67089
dc.description.abstractMitochondria have emerged recently as a novel, intriguing target for anti-caner drugs, owing largely to their importance for proper growth of cancer cells. Destabilization of mitochondria often results in the induction of apoptosis in cancer cells that, consequently, may translate into suppression of tumour growth. A class of mitochondria-targeting compounds, mitocans, comprises several groups of agents with different targets within the mitochondrion. Of these, vitamin E analogues have been recently promoted as agents that disrupt mitochondria by several modes of action. These compounds hold substantial promise as potential anti-cancer drugs of clinical relevance.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer Verlag
dc.publisher.placeUnited Kingdom
dc.publisher.urihttp://dx.doi.org/10.1007/978-94-017-8984-4
dc.relation.ispartofbooktitleMitochondria: The Anti-cancer Target for the Third Millenium
dc.relation.ispartofchapter4
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom81
dc.relation.ispartofpageto104
dc.rights.retentionY
dc.subject.fieldofresearchCancer Cell Biology
dc.subject.fieldofresearchcode111201
dc.titleMitochondrial Complex II in Cancer
dc.typeBook chapter
dc.type.descriptionB1 - Chapters
dc.type.codeB - Book Chapters
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri


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