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  • The chronic enteropathogenic disease schistosomiasis

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    Author(s)
    Olveda, David U
    Olveda, Remigio M
    McManus, Donald P
    Cai, Pengfei
    Chau, Thao NP
    Lam, Alfred K
    Li, Yuesheng
    Harn, Donald A
    Vinluan, Marilyn L
    Ross, Allen GP
    Griffith University Author(s)
    Lam, Alfred K.
    Ross, Allen G.
    Olveda, David
    McManus, Don P.
    Year published
    2014
    Metadata
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    Abstract
    Schistosomiasis is a chronic enteropathogenic disease caused by blood flukes of the genus Schistosoma. The disease afflicts approximately 240 million individuals globally, causing approximately 70 million disability-adjusted life years lost. Chronic infections with morbidity and mortality occur as a result of granuloma formation in the intestine, liver, or in the case of Schistosoma haematobium, the bladder. Various methods are utilized to diagnose and evaluate liver fibrosis due to schistosomiasis. Liver biopsy is still considered the gold standard, but it is invasive. Diagnostic imaging has proven to be an invaluable method ...
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    Schistosomiasis is a chronic enteropathogenic disease caused by blood flukes of the genus Schistosoma. The disease afflicts approximately 240 million individuals globally, causing approximately 70 million disability-adjusted life years lost. Chronic infections with morbidity and mortality occur as a result of granuloma formation in the intestine, liver, or in the case of Schistosoma haematobium, the bladder. Various methods are utilized to diagnose and evaluate liver fibrosis due to schistosomiasis. Liver biopsy is still considered the gold standard, but it is invasive. Diagnostic imaging has proven to be an invaluable method in assessing hepatic morbidity in the hospital setting, but has practical limitations in the field. The potential of non-invasive biological markers, serum antibodies, cytokines, and circulating host microRNAs to diagnose hepatic fibrosis is presently undergoing evaluation. This review provides an update on the recent advances made with respect to gastrointestinal disease associated with chronic schistosomiasis.
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    Journal Title
    International Journal of Infectious Diseases
    Volume
    28
    DOI
    https://doi.org/10.1016/j.ijid.2014.07.009
    Copyright Statement
    © The Author(s) 2014. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) License (http://creativecommons.org/licenses/by-nc-nd/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. You may not alter, transform, or build upon this work.
    Subject
    Medical Parasitology
    Microbiology
    Medical Microbiology
    Public Health and Health Services
    Publication URI
    http://hdl.handle.net/10072/67120
    Collection
    • Journal articles

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