• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Supplementation with a single and double strain probiotic on the innate immune system for respiratory illness

    Author(s)
    West, NP
    Horn, PL
    Barrett, S
    Warren, HS
    Lehtinen, MJ
    Koerbin, G
    Brun, M
    Pyne, DB
    Lahtinen, SJ
    Fricker, PA
    Cripps, AW
    Griffith University Author(s)
    Cripps, Allan W.
    West, Nic P.
    Year published
    2014
    Metadata
    Show full item record
    Abstract
    Background and aims The immune mechanisms by which probiotics reduce susceptibility to upper respiratory tract illness is uncertain. The aim of this study was to examine purported cell-mediated immune mechanisms that might explain the reduction in respiratory illness observed following daily supplementation with Bifidobacterium animalis subsp. lactis Bl-04 (Bl-04) and a combined Lactobacillus acidophilus NCFM & B. animalis subsp. lactis BI-07 (NCFM & Bi-07). Methods A cohort of 144 healthy physically active individuals were allocated to daily supplementation consumed as a beverage with Bl-04 (n = 46) supplemented at a dosage ...
    View more >
    Background and aims The immune mechanisms by which probiotics reduce susceptibility to upper respiratory tract illness is uncertain. The aim of this study was to examine purported cell-mediated immune mechanisms that might explain the reduction in respiratory illness observed following daily supplementation with Bifidobacterium animalis subsp. lactis Bl-04 (Bl-04) and a combined Lactobacillus acidophilus NCFM & B. animalis subsp. lactis BI-07 (NCFM & Bi-07). Methods A cohort of 144 healthy physically active individuals were allocated to daily supplementation consumed as a beverage with Bl-04 (n = 46) supplemented at a dosage of 2.0 נ109 colony forming units (cfu) per day, NCFM & Bi-07 (n = 47) at a dosage of 5.0 נ109 CFU per day each, or a placebo (n = 51) over 150 d. Markers included plasma cytokines, metalloproteinases and neurotrophins, peripheral blood leucocyte numbers, antibody-dependent and antibody-independent NK cell activity (NKCA), and peripheral blood mononuclear cell (PBMC) phagocytosis. Results A total of 125 subjects were included in the final analysis. No significant effects were observed on cytokines, on white cell differentials, NKCA or PBMC phagocytosis from pre- to post-supplementation. The biomarkers that increased significantly from pre- to post-supplementation were the concentration of plasma macrophage inflammatory protein (MIP)-1d which was higher in the Bl-04 than placebo group (Bl-04 25% ᠱ1%, placebo -3.3% ᠹ.4%; mean ᠓D, P = 0.003) while the concentration of plasma matrix metallo-proteinase (MMP)-1 decreased by 11% ᠱ6% in the NCFM & Bi-07 group and increased by 21% ᠱ7% in the placebo group, which was a significant 26% difference (8-41%; P = 0.02). Conclusion Probiotic supplementation had little effect on parameters of the innate immune system. Mechanisms explaining the beneficial effect of Bl-04 or NCFM & Bi-07 supplementation on respiratory illness remain unclear.
    View less >
    Journal Title
    e-SPEN Journal
    Volume
    9
    Issue
    5
    DOI
    https://doi.org/10.1016/j.clnme.2014.06.003
    Subject
    Clinical sciences
    Nutrition and dietetics
    Nutrigenomics and personalised nutrition
    Publication URI
    http://hdl.handle.net/10072/67135
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E
    • TEQSA: PRV12076

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander