Show simple item record

dc.contributor.authorWest, NP
dc.contributor.authorHorn, PL
dc.contributor.authorBarrett, S
dc.contributor.authorWarren, HS
dc.contributor.authorLehtinen, MJ
dc.contributor.authorKoerbin, G
dc.contributor.authorBrun, M
dc.contributor.authorPyne, DB
dc.contributor.authorLahtinen, SJ
dc.contributor.authorFricker, PA
dc.contributor.authorCripps, AW
dc.date.accessioned2017-05-03T15:26:06Z
dc.date.available2017-05-03T15:26:06Z
dc.date.issued2014
dc.identifier.issn2212-8263
dc.identifier.doi10.1016/j.clnme.2014.06.003
dc.identifier.urihttp://hdl.handle.net/10072/67135
dc.description.abstractBackground and aims The immune mechanisms by which probiotics reduce susceptibility to upper respiratory tract illness is uncertain. The aim of this study was to examine purported cell-mediated immune mechanisms that might explain the reduction in respiratory illness observed following daily supplementation with Bifidobacterium animalis subsp. lactis Bl-04 (Bl-04) and a combined Lactobacillus acidophilus NCFM & B. animalis subsp. lactis BI-07 (NCFM & Bi-07). Methods A cohort of 144 healthy physically active individuals were allocated to daily supplementation consumed as a beverage with Bl-04 (n = 46) supplemented at a dosage of 2.0 נ109 colony forming units (cfu) per day, NCFM & Bi-07 (n = 47) at a dosage of 5.0 נ109 CFU per day each, or a placebo (n = 51) over 150 d. Markers included plasma cytokines, metalloproteinases and neurotrophins, peripheral blood leucocyte numbers, antibody-dependent and antibody-independent NK cell activity (NKCA), and peripheral blood mononuclear cell (PBMC) phagocytosis. Results A total of 125 subjects were included in the final analysis. No significant effects were observed on cytokines, on white cell differentials, NKCA or PBMC phagocytosis from pre- to post-supplementation. The biomarkers that increased significantly from pre- to post-supplementation were the concentration of plasma macrophage inflammatory protein (MIP)-1d which was higher in the Bl-04 than placebo group (Bl-04 25% ᠱ1%, placebo -3.3% ᠹ.4%; mean ᠓D, P = 0.003) while the concentration of plasma matrix metallo-proteinase (MMP)-1 decreased by 11% ᠱ6% in the NCFM & Bi-07 group and increased by 21% ᠱ7% in the placebo group, which was a significant 26% difference (8-41%; P = 0.02). Conclusion Probiotic supplementation had little effect on parameters of the innate immune system. Mechanisms explaining the beneficial effect of Bl-04 or NCFM & Bi-07 supplementation on respiratory illness remain unclear.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrome178
dc.relation.ispartofpagetoe184
dc.relation.ispartofissue5
dc.relation.ispartofjournale-SPEN Journal
dc.relation.ispartofvolume9
dc.rights.retentionY
dc.subject.fieldofresearchDietetics and Nutrigenomics
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchNutrition and Dietetics
dc.subject.fieldofresearchcode111102
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1111
dc.titleSupplementation with a single and double strain probiotic on the innate immune system for respiratory illness
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Allied Health Sciences
gro.hasfulltextNo Full Text
gro.griffith.authorPyne, David B.
gro.griffith.authorBarrett, Susan
gro.griffith.authorCripps, Allan W.
gro.griffith.authorWest, Nic P.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record