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dc.contributor.authorDong, LF
dc.contributor.authorNeuzil, J
dc.contributor.editorJ. Neuzil, S. Pervaiz and S. Fulda
dc.date.accessioned2017-11-28T12:01:23Z
dc.date.available2017-11-28T12:01:23Z
dc.date.issued2014
dc.identifier.isbn9789401789837
dc.identifier.doi10.1007/978-94-017-8984-4_7
dc.identifier.urihttp://hdl.handle.net/10072/67138
dc.description.abstractMitochondria have emerged recently as a novel, intriguing target for anti-caner drugs, owing largely to their importance for proper growth of cancer cells. Destabilization of mitochondria often results in the induction of apoptosis in cancer cells that, consequently, may translate into suppression of tumour growth. A class of mitochondria-targeting compounds, mitocans, comprises several groups of agents with different targets within the mitochondrion. Of these, vitamin E analogues have been recently promoted as agents that disrupt mitochondria by several modes of action. These compounds hold substantial promise as potential anti-cancer drugs of clinical relevance.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer Verlag
dc.publisher.placeUnited Kingdom
dc.publisher.urihttp://dx.doi.org/10.1007/978-94-017-8984-4
dc.relation.ispartofbooktitleMitochondria: The Anti-cancer Target for the Third Millenium
dc.relation.ispartofchapter7
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom151
dc.relation.ispartofpageto181
dc.rights.retentionY
dc.subject.fieldofresearchMolecular Targets
dc.subject.fieldofresearchCancer Cell Biology
dc.subject.fieldofresearchcode111207
dc.subject.fieldofresearchcode111201
dc.titleVitamin E analogues as prototypic mitochondria-targeting anti-cancer agents
dc.typeBook chapter
dc.type.descriptionB1 - Chapters
dc.type.codeB - Book Chapters
gro.facultyGriffith Health, School of Medical Science
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri
gro.griffith.authorDong, Lan-feng


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