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dc.contributor.authorMitchell, Lana J
dc.contributor.authorDavidson, Zoe E
dc.contributor.authorBonham, Maxine
dc.contributor.authorO'Driscoll, Denise M
dc.contributor.authorHamilton, Garun S
dc.contributor.authorTruby, Helen
dc.date.accessioned2017-05-03T16:18:22Z
dc.date.available2017-05-03T16:18:22Z
dc.date.issued2014
dc.identifier.issn1389-9457
dc.identifier.doi10.1016/j.sleep.2014.05.012
dc.identifier.urihttp://hdl.handle.net/10072/67201
dc.description.abstractBackground Excess body weight is a risk factor for obstructive sleep apnoea (OSA). The aim of the systematic review was to establish whether weight loss via lifestyle interventions such as diet and exercise are useful in the treatment of OSA. Methods A literature search was conducted between 1980 and February 2012. Systematic reviews and randomised controlled trials (RCTs) with participants who had OSA, were overweight or obese, and who had undergone lifestyle interventions with the aim of improving sleep apnoea were included. Meta analyses were conducted for a subset of RCTs with appropriate data. Results Two systematic reviews and eight RCTs were included. Meta-analyses were conducted for four RCTs comparing intensive lifestyle interventions to a control. The overall weighted mean differences for weight change, change in apnoea -hypopnoea index (AHI) and change in oxygen desaturation index of =4% were as follows: -13.76 kg (95% confidence interval (CI) -19.21, --8.32), -16.09 (95% CI -25.64, -6.54) and -14.18 (95% CI -24.23, -4.13), respectively. Although high heterogeneity within the meta analyses, all studies favoured the interventions. Long-term follow-up data from three RCTs suggest that improvements in weight and AHI are maintained for up to 60 months. Conclusions Intensive lifestyle interventions are effective in the treatment of OSA, resulting in significant weight loss and a reduction in sleep apnoea severity. Weight loss via intensive lifestyle interventions could be encouraged as a treatment for mild to moderate OSA.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1173
dc.relation.ispartofpageto1183
dc.relation.ispartofissue10
dc.relation.ispartofjournalSleep Medicine
dc.relation.ispartofvolume15
dc.rights.retentionY
dc.subject.fieldofresearchNutrition and Dietetics not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode111199
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1701
dc.titleWeight loss from lifestyle interventions and severity of sleep apnoea: A systematic review and meta-analysis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorMitchell, Lana J.


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