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dc.contributor.authorDong, Lan-Feng
dc.contributor.authorNeuzil, Jiri
dc.contributor.editorOsiewacz, HD
dc.date.accessioned2017-05-03T15:05:23Z
dc.date.available2017-05-03T15:05:23Z
dc.date.issued2014
dc.identifier.issn1877-1173
dc.identifier.doi10.1016/B978-0-12-394625-6.00008-8
dc.identifier.urihttp://hdl.handle.net/10072/67202
dc.description.abstractCancer can be characterized as a state of multifaceted cellular deregulation including control of proliferation and bioenergetics. The latter involves in particular mitochondria, the site of the generation of ATP, essential for the proper cellular function (including proliferation). Mitochondria also contain a variety of proteins that are necessary for the induction/promotion, as well as for the prevention of cell death. Therefore, mitochondria are pivotal in deciding the fate of a cell. In cancer, mitochondria are dysfunctional, which was observed as early as in the 1930s by Otto Warburg. Due to the central role of mitochondria, these organelles, endowed with its own DNA, are a focus of research as possible "culprits" for the malignancy of cancer cells (or at least contributing to this phenotype) and, importantly, as emerging targets for anticancer therapy.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAcademic Press
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom211
dc.relation.ispartofpageto227
dc.relation.ispartofjournalProgress in Molecular Biology and Translational Science
dc.relation.ispartofvolume127
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and biomolecular chemistry not elsewhere classified
dc.subject.fieldofresearchMolecular targets
dc.subject.fieldofresearchcode340499
dc.subject.fieldofresearchcode321108
dc.titleMitochondria in cancer: why mitochondria are a good target for cancer therapy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri


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