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  • Malignant insulinoma with hepatoid differentiation: A unique case with alpha-fetoprotein production

    Author(s)
    Lam, KY
    Lo, CY
    Wat, MS
    Fan, ST
    Griffith University Author(s)
    Lam, Alfred K.
    Year published
    2001
    Metadata
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    Abstract
    Hepatoid carcinomas are uncommon extra-hepatic neoplasms exhibiting features of hepatocellular carcinoma and they are most frequently described in the stomach. We report a 64-yr-old woman with a malignant insulinoma showing focal hepatoid differentiation and biochemical evidence of alpha-fetoprotein (AFP) production. The current case is the first malignant insulinoma with hepatoid differentiation. Resection of the primary tumor followed by regional embolization was performed. The patient died 22 mo after initial presentation. Thus, the presence of hepatoid differentiation in pancreatic tumor should be noted as the tumor may ...
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    Hepatoid carcinomas are uncommon extra-hepatic neoplasms exhibiting features of hepatocellular carcinoma and they are most frequently described in the stomach. We report a 64-yr-old woman with a malignant insulinoma showing focal hepatoid differentiation and biochemical evidence of alpha-fetoprotein (AFP) production. The current case is the first malignant insulinoma with hepatoid differentiation. Resection of the primary tumor followed by regional embolization was performed. The patient died 22 mo after initial presentation. Thus, the presence of hepatoid differentiation in pancreatic tumor should be noted as the tumor may be associated with elevated AFP. The features of pancreatic hepatoid carcinomas are discussed.
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    Journal Title
    Endocrine Pathology
    Volume
    12
    Issue
    3
    DOI
    https://doi.org/10.1385/EP:12:3:351
    Subject
    Clinical Sciences
    Publication URI
    http://hdl.handle.net/10072/67391
    Collection
    • Journal articles

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