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  • The effects of multimodal exercise on cognitive and physical functioning and brain-derived neurotrophic factor in older women: a randomised controlled trial

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    Author(s)
    Vaughan, Sue
    Wallis, Marianne
    Polit, Denise
    Steele, Mike
    Shum, David
    Morris, Norman
    Griffith University Author(s)
    Shum, David
    Wallis, Marianne
    Steele, Mike
    Morris, Norman
    Polit, Denise F.
    Vaughan, Sue
    Year published
    2014
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    Abstract
    Objective: to test the effect of a 16-week multimodal exercise program on neurocognitive and physical functioning and brain-derived neurotrophic factor (BDNF). Design: a single-blinded, parallel-group randomised controlled trial. Settings: university campus and community-based halls. Subjects: forty-nine women aged 65 to 75 years, with no cognitive impairment and not undertaking more than 1 h of formal exercise training per week. Methods: the intervention group attended a 60-min multimodal class twice each week which included cardiovascular, strength and motor fitness training. The primary outcome was neurocognitive ...
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    Objective: to test the effect of a 16-week multimodal exercise program on neurocognitive and physical functioning and brain-derived neurotrophic factor (BDNF). Design: a single-blinded, parallel-group randomised controlled trial. Settings: university campus and community-based halls. Subjects: forty-nine women aged 65 to 75 years, with no cognitive impairment and not undertaking more than 1 h of formal exercise training per week. Methods: the intervention group attended a 60-min multimodal class twice each week which included cardiovascular, strength and motor fitness training. The primary outcome was neurocognitive functioning and secondary outcomes were physical functioning and plasma levels of BDNF. Results: twenty-five participants were randomised to the intervention group and 24 to the control group. One control participant withdrew before follow-up data collection. The intervention group performed significantly better than the control group at follow-up (when controlled for baseline) in the Trail Making test A and B, the California Older Adult Stroop test (Word, Interference and Total scores), Controlled Oral Word Association test and the Timed Up-and-Go test, Six-Minute Walk test, One-Legged Stance test and plasma BDNF. Conclusion: this multimodal exercise program resulted in neurocognitive and physical performance improvements and increased levels of plasma BDNF, in older women, when compared with controls. This RCT provides evidence that a multimodal exercise intervention can achieve larger effect sizes than those generally resulting from single modality interventions. Increases in BDNF levels imply neurogenesis may be a component of the mechanism underpinning the cognitive improvements associated with multimodal exercise. Trial registration: Australian and New Zealand Clinical Trial Registration Number: ANZCTR12612000451808.
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    Journal Title
    Age and Ageing
    Volume
    43
    DOI
    https://doi.org/10.1093/ageing/afu010
    Copyright Statement
    © 2014 Australian Journal of Outdoor Education. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Age and Ageing following peer review. The definitive publisher-authenticated version, The effects of multi-modal exercise on cognitive and physical functioning and brain-derived neurotrophic factor in older women: a randomised controlled trial, Age and Ageing, Vol. 43, pp. 623-629, 2014, is available online at: http://dx.doi.org/10.1093/ageing/afu010.
    Subject
    Clinical sciences
    Clinical sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/67458
    Collection
    • Journal articles

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