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dc.contributor.authorWebb, DC
dc.contributor.authorCripps, AW
dc.date.accessioned2017-09-06T02:44:46Z
dc.date.available2017-09-06T02:44:46Z
dc.date.issued2000
dc.identifier.issn0019-9567
dc.identifier.doi10.1128/IAI.68.1.377-381.2000
dc.identifier.urihttp://hdl.handle.net/10072/67467
dc.description.abstractNontypeable Haemophilus influenzae (NTHi) is an opportunistic pathogen associated with otitis media and the exacerbation of chronic bronchitis. This study reports the vaccine potential of three peptides representing conserved regions of the NTHi P5 outer membrane protein which have been fused to a promiscuous measles virus F protein T-cell eptitope (MVF). The peptides correspond to a region in surface loop one (MVF/L1A), the central region of loop four (MVF/L4), and a C-terminal region homologous to peptide 10 of OprF from Pseudomonas aeruginosa (MVF/H3). Immunization of rats with MVF/H3 was the most efficacious in significantly reducing the number of viable NTHi in both the broncho-alveolar lavage fluid (74%) and lung homogenates (70%), compared to control rats. Importantly, despite significantly increased rates of clearance, immunization with MVF/H3 elicited poor antibody responses, suggesting that cell-mediated rather than humoral responses play an important role in the enhanced clearance of NTHi in this model.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Society for Microbiology
dc.publisher.placeWashington, DC
dc.relation.ispartofpagefrom377
dc.relation.ispartofpageto381
dc.relation.ispartofissue1
dc.relation.ispartofjournalInfection and Immunity
dc.relation.ispartofvolume68
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchAgricultural, veterinary and food sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode30
dc.subject.fieldofresearchcode32
dc.titleA P5 Peptide That Is Homologous to Peptide 10 of OprF from Pseudomonas aeruginosa Enhances Clearance of Nontypeable Haemophilus influenzae from Acutely Infected Rat Lung in the Absence of Detectable Peptide-Specific Antibody
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
dc.description.versionVersion of Record (VoR)
gro.facultyGriffith Health Faculty
gro.rights.copyright© 2000 American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorCripps, Allan W.


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