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dc.contributor.authorLopez, Alejandro
dc.contributor.authorWeilenman, Christophe
dc.contributor.authorAudran, Régine
dc.contributor.authorRoggero, Mario A.
dc.contributor.authorBonelo, Anilza
dc.contributor.authorTiercy, Jean-Marie
dc.contributor.authorSpertini, François
dc.contributor.authorCorradin, Giampietro
dc.date.accessioned2011-05-10
dc.date.accessioned2015-04-29T23:48:16Z
dc.date.accessioned2017-03-01T23:38:40Z
dc.date.available2015-04-29T23:48:16Z
dc.date.available2017-03-01T23:38:40Z
dc.date.issued2001
dc.identifier.issn1521-4141 0014-2980
dc.identifier.doi10.1002/1521-4141(200107)31:7<1989::AID-IMMU1989>3.0.CO;2-M
dc.identifier.urihttp://hdl.handle.net/10072/67471
dc.description.abstractWe report the first synthetic peptide vaccine eliciting strong CD8+ and CD4+ T lymphocyte responses in humans. The vaccine, representing the C-terminal region of the circumsporozoite protein of Plasmodium falciparum (amino acids 282–383) was well tolerated and strong sporozoite-specific antibodies were elicited. In addition, robust lymphocyte proliferation responses were equally elicited with concomitant in vitro production of IFN- + , crucial in the elimination of the parasite. Most importantly, we also observed the development of CD8+ T lymphocyte responses decisive in the immunity to malaria. The latter finding opens new, possibly safer, avenues for vaccination strategies when a CD8+ T cell response is needed.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.publisherWiley-VCH
dc.publisher.placeWeihheim, Germany
dc.relation.ispartofpagefrom1989
dc.relation.ispartofpageto1998
dc.relation.ispartofissue7
dc.relation.ispartofjournalEuropean Journal of Immunology
dc.relation.ispartofvolume31
dc.subject.fieldofresearchCellular Immunology
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode110704
dc.subject.fieldofresearchcode1107
dc.titleA synthetic malaria vaccine elicits a potent CD8+ and CD4+ T lymphocyte immune response in humans. Implications for vaccination strategies
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyFaculty of Science, Environment, Engineering and Technology
gro.hasfulltextNo Full Text
gro.griffith.authorLopez Ramirez, Alejandro


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