Show simple item record

dc.contributor.authorWeible, Michael
dc.date.accessioned2011-08-07
dc.date.accessioned2015-04-29T23:48:19Z
dc.date.accessioned2017-03-01T23:38:40Z
dc.date.available2015-04-29T23:48:19Z
dc.date.available2017-03-01T23:38:40Z
dc.date.issued2000
dc.identifier.issn0818-9641
dc.identifier.doi10.1046/j.1440-1711.2000.00924.x
dc.identifier.urihttp://hdl.handle.net/10072/67472
dc.description.abstractThe retrograde axonal transport of neurotrophins occurs after receptor-mediated endocytosis into vesicles at the nerve terminal. We have been investigating the process of targeting these vesicles for retrograde transport, by examining the transport of [125I]-labelled neurotrophins from the eye to sympathetic and sensory ganglia. With the aid of confocal microscopy, we examined the phenomena further in cultures of dissociated sympathetic ganglia to which rhodamine-labelled nerve growth factor (NGF) was added. We found the label in large vesicles in the growth cone and axons. Light microscopic examination of the sympathetic nerve trunk in vivo also showed the retrogradely transported material to be sporadically located in large structures in the axons. Ultrastructural examination of the sympathetic nerve trunk after the transport of NGF bound to gold particles showed the label to be concentrated in relatively few large organelles that consisted of accumulations of multivesicular bodies. These results suggest that in vivo NGF is transported in specialized organelles that require assembly in the nerve terminal.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.publisherBlackwell Publishing
dc.publisher.placeEngland
dc.relation.ispartofpagefrom430
dc.relation.ispartofpageto435
dc.relation.ispartofissue2
dc.relation.ispartofjournalImmunology and cell biology
dc.relation.ispartofvolume62
dc.subject.fieldofresearchCellular Nervous System
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode110902
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1107
dc.titleSignalling organelle for retrograde axonal transport of internalized neurotrophins from the nerve terminal.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyFaculty of Science, Environment, Engineering and Technology
gro.hasfulltextNo Full Text
gro.griffith.authorWeible, Michael W.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record