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dc.contributor.authorAppia-Ayme, Corinne
dc.contributor.authorPatrick, Elaine
dc.contributor.authorSullivan, Matthew J
dc.contributor.authorAlston, Mark J
dc.contributor.authorField, Sarah J
dc.contributor.authorAbuOun, Manal
dc.contributor.authorAnjum, Muna F
dc.contributor.authorRowley, Gary
dc.date.accessioned2017-05-03T16:17:51Z
dc.date.available2017-05-03T16:17:51Z
dc.date.issued2011
dc.identifier.issn1932-6203
dc.identifier.doi10.1371/journal.pone.0023713
dc.identifier.urihttp://hdl.handle.net/10072/67522
dc.description.abstractThe RpoE and CpxR regulated envelope stress responses are extremely important for SalmonellaTyphimurium to cause infection in a range of hosts. Until now the role for BaeSR in both the Salmonella Typhimurium response to stress and its contribution to infection have not been fully elucidated. Here we demonstrate stationary phase growth, iron and sodium tungstate as novel inducers of the BaeRregulon, with BaeR critically required for Salmonella resistance to sodium tungstate. We show that functional overlap between the resistance nodulation-cell division (RND) multidrug transporters, MdtA, AcrD and AcrB exists for the waste disposal of tungstate from the cell. We also point to a role for enterobactinsiderophores in the protection of enteric organisms from tungstate, akin to the scenario in nitrogen fixing bacteria. Surprisingly, BaeR is the first envelope stress response pathway investigated in S. Typhimurium that is not required for murine typhoid in either ityS or ityR mouse backgrounds. BaeR is therefore either required for survival in larger mammals such as pigs or calves, an avian host such as chickens, or survival out with the host altogether where Salmonella and related enterics must survive in soil and water.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent556065 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherPublic Library of Science
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrome23713-1
dc.relation.ispartofpagetoe23713-12
dc.relation.ispartofissue8
dc.relation.ispartofjournalPloS One
dc.relation.ispartofvolume6
dc.rights.retentionY
dc.subject.fieldofresearchBacteriology
dc.subject.fieldofresearchMicrobial genetics
dc.subject.fieldofresearchcode310701
dc.subject.fieldofresearchcode310704
dc.titleNovel Inducers of the Envelope Stress Response BaeSR in Salmonella Typhimurium: BaeR Is Critically Required for Tungstate Waste Disposal
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2011 Appia-Ayme et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
gro.hasfulltextFull Text
gro.griffith.authorSullivan, Matthew J.


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