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dc.contributor.authorZhou, Fu-Chun
dc.contributor.authorHou, Wei-Min
dc.contributor.authorWang, Chuan-Yue
dc.contributor.authorUngvari, Gabor S
dc.contributor.authorChiu, Helen FK
dc.contributor.authorCorrell, Christoph U
dc.contributor.authorShum, David HK
dc.contributor.authorMan, David
dc.contributor.authorLiu, Deng-Tang
dc.contributor.authorXiang, Yu-Tao
dc.date.accessioned2017-05-03T11:56:16Z
dc.date.available2017-05-03T11:56:16Z
dc.date.issued2014
dc.identifier.issn1932-6203
dc.identifier.doi10.1371/journal.pone.0111562
dc.identifier.urihttp://hdl.handle.net/10072/67541
dc.description.abstractObjective We aimed at investigating prospective memory and its socio-demographic and neurocognitive correlates in non-psychotic, first-degree relatives (FDRs) of patients with schizophrenia compared to patients with first episode schizophrenia (FES), and healthy controls (HCs). Methods Forty-seven FES patients, 50 non-psychotic FDRs (23 offspring and 27 siblings) of patients with chronic schizophrenia (unrelated to the FES group) and 51 HCs were studied. The Chinese version of the Cambridge Prospective Memory Test (C-CAMPROMPT) was used to measure time-based prospective memory (TBPM) and event-based prospective memory (EBPM) performance. Other cognitive functions (involving respective memory and executive functions) were evaluated with standardized tests. Results After controlling for basic demographic characteristics including age, gender and educational level, there was a significant difference between FDRs, FES and HCs with respect to both TBPM (F(2,142) = 10.4, p<0.001) and EBPM (F(2,142) = 10.8, p<0.001). Multiple linear regression analyses revealed that lower scores of the Hopkins Verbal Learning Test-Revised (HVLT-R) and the STROOP Word-Color Test (SWCT) contributed to TBPM impairment, while lower educational level and higher scores of the Color Trails Test-2 (CTT-2) contributed to EBPM deficit in FDRs. Conclusions FDRs share similar but attenuated prospective memory impairments with schizophrenia patients, suggesting that prospective memory deficits may represent an endophenotype of schizophrenia.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent218749 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherPublic Library of Science
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrome111562-1
dc.relation.ispartofpagetoe111562-8
dc.relation.ispartofissue11
dc.relation.ispartofjournalPloS One
dc.relation.ispartofvolume9
dc.rights.retentionY
dc.subject.fieldofresearchBiological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
dc.subject.fieldofresearchcode170101
dc.titleProspective Memory Performance in Non-Psychotic First-Degree Relatives of Patients with Schizophrenia: A Controlled Study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2014 Zhou et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
gro.hasfulltextFull Text
gro.griffith.authorShum, David


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