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  • Multiphasic scaffolds for periodontal tissue engineering

    Author(s)
    Ivanovski, S
    Vaquette, C
    Gronthos, S
    Hutmacher, DW
    Bartold, PM
    Griffith University Author(s)
    Ivanovski, Saso
    Vaquette, Cedryck
    Hutmacher, Dietmar W.
    Year published
    2014
    Metadata
    Show full item record
    Abstract
    For a successful clinical outcome, periodontal regeneration requires the coordinated response of multiple soft and hard tissues (periodontal ligament, gingiva, cementum, and bone) during the wound-healing process. Tissue-engineered constructs for regeneration of the periodontium must be of a complex 3-dimensional shape and adequate size and demonstrate biomechanical stability over time. A critical requirement is the ability to promote the formation of functional periodontal attachment between regenerated alveolar bone, and newly formed cementum on the root surface. This review outlines the current advances in multiphasic ...
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    For a successful clinical outcome, periodontal regeneration requires the coordinated response of multiple soft and hard tissues (periodontal ligament, gingiva, cementum, and bone) during the wound-healing process. Tissue-engineered constructs for regeneration of the periodontium must be of a complex 3-dimensional shape and adequate size and demonstrate biomechanical stability over time. A critical requirement is the ability to promote the formation of functional periodontal attachment between regenerated alveolar bone, and newly formed cementum on the root surface. This review outlines the current advances in multiphasic scaffold fabrication and how these scaffolds can be combined with cell- and growth factor-based approaches to form tissue-engineered constructs capable of recapitulating the complex temporal and spatial wound-healing events that will lead to predictable periodontal regeneration. This can be achieved through a variety of approaches, with promising strategies characterized by the use of scaffolds that can deliver and stabilize cells capable of cementogenesis onto the root surface, provide biomechanical cues that encourage perpendicular alignment of periodontal fibers to the root surface, and provide osteogenic cues and appropriate space to facilitate bone regeneration. Progress on the development of multiphasic constructs for periodontal tissue engineering is in the early stages of development, and these constructs need to be tested in large animal models and, ultimately, human clinical trials.
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    Journal Title
    Journal of Dental Research
    Volume
    93
    Issue
    12
    DOI
    https://doi.org/10.1177/0022034514544301
    Subject
    Dentistry
    Dentistry not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/67653
    Collection
    • Journal articles

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