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dc.contributor.authorIvanovski, S
dc.contributor.authorVaquette, C
dc.contributor.authorGronthos, S
dc.contributor.authorHutmacher, DW
dc.contributor.authorBartold, PM
dc.date.accessioned2017-05-03T12:42:37Z
dc.date.available2017-05-03T12:42:37Z
dc.date.issued2014
dc.identifier.issn0022-0345
dc.identifier.doi10.1177/0022034514544301
dc.identifier.urihttp://hdl.handle.net/10072/67653
dc.description.abstractFor a successful clinical outcome, periodontal regeneration requires the coordinated response of multiple soft and hard tissues (periodontal ligament, gingiva, cementum, and bone) during the wound-healing process. Tissue-engineered constructs for regeneration of the periodontium must be of a complex 3-dimensional shape and adequate size and demonstrate biomechanical stability over time. A critical requirement is the ability to promote the formation of functional periodontal attachment between regenerated alveolar bone, and newly formed cementum on the root surface. This review outlines the current advances in multiphasic scaffold fabrication and how these scaffolds can be combined with cell- and growth factor-based approaches to form tissue-engineered constructs capable of recapitulating the complex temporal and spatial wound-healing events that will lead to predictable periodontal regeneration. This can be achieved through a variety of approaches, with promising strategies characterized by the use of scaffolds that can deliver and stabilize cells capable of cementogenesis onto the root surface, provide biomechanical cues that encourage perpendicular alignment of periodontal fibers to the root surface, and provide osteogenic cues and appropriate space to facilitate bone regeneration. Progress on the development of multiphasic constructs for periodontal tissue engineering is in the early stages of development, and these constructs need to be tested in large animal models and, ultimately, human clinical trials.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSage Publications
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1212
dc.relation.ispartofpageto1221
dc.relation.ispartofissue12
dc.relation.ispartofjournalJournal of Dental Research
dc.relation.ispartofvolume93
dc.rights.retentionY
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchDentistry not elsewhere classified
dc.subject.fieldofresearchcode3203
dc.subject.fieldofresearchcode320399
dc.titleMultiphasic scaffolds for periodontal tissue engineering
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Dentistry and Oral Health
gro.hasfulltextNo Full Text
gro.griffith.authorIvanovski, Saso
gro.griffith.authorVaquette, Cedryck
gro.griffith.authorHutmacher, Dietmar W.


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