Alpha-synuclein repeat variants and survival in Parkinson's disease
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Objectives To determine whether a-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results Twenty-one sites contributed data for 6,154 cases. There was no significant association between a-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value?=?0.01). Conclusions In our large consortium study, a-synuclein REP1 genotypes were not associated with survival in PD. Further studies of a-synuclein's role in disease progression and long-term outcomes are needed.
© 2014 Movement Disorder Society. This is the pre-peer reviewed version of the following article: Alpha-synuclein repeat variants and survival in Parkinson's disease, Movement Disorders, Volume 29, Issue 8, July 2014, Pages 1053-1057, which has been published in final form at https://doi.org/10.1002/mds.25841. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
Neurology and Neuromuscular Diseases