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dc.contributor.authorChung, Sun Ju
dc.contributor.authorBiernacka, Joanna M
dc.contributor.authorArmasu, Sebastian M
dc.contributor.authorAnderson, Kari
dc.contributor.authorFrigerio, Roberta
dc.contributor.authorAasly, Jan O
dc.contributor.authorAnnesi, Grazia
dc.contributor.authorBentivoglio, Anna Rita
dc.contributor.authorBrighina, Laura
dc.contributor.authorChartier-Harlin, Marie-Christine
dc.contributor.authorGoldwurm, Stefano
dc.contributor.authorHadjigeorgiou, Georgios
dc.contributor.authorJasinska-Myga, Barbara
dc.contributor.authorJeon, Beom Seok
dc.contributor.authorKim, Yun Joong
dc.contributor.authorKrueger, Rejko
dc.contributor.authorLesage, Suzanne
dc.contributor.authorMarkopoulou, Katerina
dc.contributor.authorMellick, George
dc.contributor.authorMorrison, Karen E
dc.contributor.authorPuschmann, Andreas
dc.contributor.authorTan, Eng-King
dc.contributor.authorCrosiers, David
dc.contributor.authorTheuns, Jessie
dc.contributor.authorVan Broeckhoven, Christine
dc.contributor.authorWirdefeldt, Karin
dc.contributor.authorWszolek, Zbigniew K
dc.contributor.authorElbaz, Alexis
dc.contributor.authorMaraganore, Demetrius M
dc.date.accessioned2018-07-31T03:37:55Z
dc.date.available2018-07-31T03:37:55Z
dc.date.issued2014
dc.identifier.issn0885-3185
dc.identifier.doi10.1002/mds.25841
dc.identifier.urihttp://hdl.handle.net/10072/67744
dc.description.abstractObjectives To determine whether a-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results Twenty-one sites contributed data for 6,154 cases. There was no significant association between a-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value?=?0.01). Conclusions In our large consortium study, a-synuclein REP1 genotypes were not associated with survival in PD. Further studies of a-synuclein's role in disease progression and long-term outcomes are needed.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1053
dc.relation.ispartofpageto1057
dc.relation.ispartofissue8
dc.relation.ispartofjournalMovement Disorders
dc.relation.ispartofvolume29
dc.rights.retentionY
dc.subject.fieldofresearchNeurology and Neuromuscular Diseases
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchHuman Movement and Sports Sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode110904
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1106
dc.subject.fieldofresearchcode1109
dc.titleAlpha-synuclein repeat variants and survival in Parkinson's disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2014 Movement Disorder Society. This is the pre-peer reviewed version of the following article: Alpha-synuclein repeat variants and survival in Parkinson's disease, Movement Disorders, Volume 29, Issue 8, July 2014, Pages 1053-1057, which has been published in final form at https://doi.org/10.1002/mds.25841. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
gro.date.issued2015-05-31T22:16:38Z
gro.hasfulltextFull Text
gro.griffith.authorMellick, George


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