Synthetic disialyl hexasaccharides protect neonatal rats from necrotizing enterocolitis
Author(s)
Yu, H
Lau, K
Thon, V
Autran, CA
Jantscher-Krenn, E
Xue, M
Li, Y
Sugiarto, G
Qu, J
Mu, S
Ding, L
Bode, L
Chen, X
Griffith University Author(s)
Year published
2014
Metadata
Show full item recordAbstract
Two novel synthetic a2-6-linked disialyl hexasaccharides, disialyllacto-N-neotetraose (DSLNnT) and a2-6-linked disialyllacto-N-tetraose (DS'LNT), were readily obtained by highly efficient one-pot multienzyme (OPME) reactions. The sequential OPME systems described herein allowed the use of an inexpensive disaccharide and simple monosaccharides to synthesize the desired complex oligosaccharides with high efficiency and selectivity. DSLNnT and DS'LNT were shown to protect neonatal rats from necrotizing enterocolitis (NEC) and are good therapeutic candidates for preclinical experiments and clinical application in treating NEC ...
View more >Two novel synthetic a2-6-linked disialyl hexasaccharides, disialyllacto-N-neotetraose (DSLNnT) and a2-6-linked disialyllacto-N-tetraose (DS'LNT), were readily obtained by highly efficient one-pot multienzyme (OPME) reactions. The sequential OPME systems described herein allowed the use of an inexpensive disaccharide and simple monosaccharides to synthesize the desired complex oligosaccharides with high efficiency and selectivity. DSLNnT and DS'LNT were shown to protect neonatal rats from necrotizing enterocolitis (NEC) and are good therapeutic candidates for preclinical experiments and clinical application in treating NEC in preterm infants.
View less >
View more >Two novel synthetic a2-6-linked disialyl hexasaccharides, disialyllacto-N-neotetraose (DSLNnT) and a2-6-linked disialyllacto-N-tetraose (DS'LNT), were readily obtained by highly efficient one-pot multienzyme (OPME) reactions. The sequential OPME systems described herein allowed the use of an inexpensive disaccharide and simple monosaccharides to synthesize the desired complex oligosaccharides with high efficiency and selectivity. DSLNnT and DS'LNT were shown to protect neonatal rats from necrotizing enterocolitis (NEC) and are good therapeutic candidates for preclinical experiments and clinical application in treating NEC in preterm infants.
View less >
Journal Title
Angew. Chem. Int. Ed
Volume
53
Issue
26
Subject
Chemical sciences
Biologically active molecules