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  • Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 Ligand) in vivo

    Author(s)
    Weber, T
    Lu, M
    Andera, L
    Lahm, H
    Gellert, N
    Fariss, MW
    Korinek, V
    Sattler, W
    Ucker, DS
    Terman, A
    Schroder, A
    Erl, W
    Brunk, UT
    Coffey, RJ
    Weber, C
    Neuzil, J
    Griffith University Author(s)
    Neuzil, Jiri
    Year published
    2002
    Metadata
    Show full item record
    Abstract
    a -Tocopheryl succinate (a -TOS), a redox-inactive analogue of vitamin E, is a strong inducer of apoptosis, whereas -tocopherol (a -TOH) lacks apoptogenic activity (J. Neuzil et al., FASEB J., 15: 403-415, 2001). Here we investigated the possible antineoplastic activities of a -TOH and a -TOS and further explored the potential of -TOS as an antitumor agent. Using nude mice with colon cancer xenografts, we found that a -TOH exerted modest antitumor activity and acted by inhibiting tumor cell proliferation. In contrast, a -TOS showed a more profound antitumor effect, at both the level of inhibition of proliferation and induction ...
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    a -Tocopheryl succinate (a -TOS), a redox-inactive analogue of vitamin E, is a strong inducer of apoptosis, whereas -tocopherol (a -TOH) lacks apoptogenic activity (J. Neuzil et al., FASEB J., 15: 403-415, 2001). Here we investigated the possible antineoplastic activities of a -TOH and a -TOS and further explored the potential of -TOS as an antitumor agent. Using nude mice with colon cancer xenografts, we found that a -TOH exerted modest antitumor activity and acted by inhibiting tumor cell proliferation. In contrast, a -TOS showed a more profound antitumor effect, at both the level of inhibition of proliferation and induction of tumor cell apoptosis. a -TOS was nontoxic to normal cells and tissues, triggered apoptosis in p53-/- and p21Waf1/Cip1(-/-) cancer cells, and exerted a cooperative proapoptotic activity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) due to differences in proapoptotic signaling. Finally, a -TOS cooperated with tumor necrosis factor-related apoptosis-inducing ligand in suppression of tumor growth in vivo. Vitamin E succinate is thus a potent and highly specific anticancer agent and/or adjuvant of considerable therapeutic potential.
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    Journal Title
    Clinical Cancer Research
    Volume
    8
    Issue
    3
    Publisher URI
    http://clincancerres.aacrjournals.org/
    http://clincancerres.aacrjournals.org/cgi/content/full/8/3/863
    Copyright Statement
    © 2002 AACR. Please refer to the journal link for access to the definitive, published version.
    Subject
    Oncology and carcinogenesis
    Publication URI
    http://hdl.handle.net/10072/6784
    Collection
    • Journal articles

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