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  • Cytokine profiles of chronic fatigue syndrome and multiple sclerosis patients.

    Author(s)
    Wong, Naomi
    Brenu, Ekua
    Hardcastle, Sharni
    Johnston, Samantha
    Thao, Nguyen
    Huth, Teilah
    Hawthorn, Ally
    Passmore, Rachel
    Ramos, Sandra
    Salajegheh, Ali
    Broadley, Simon
    Staines, Don
    Marshall-Gradisnik, Sonya
    Griffith University Author(s)
    Staines, Don R.
    Broadley, Simon
    Ariana, Armin S.
    Hardcastle, Sharni L.
    Huth, Teilah K.
    Ramos, Sandra B.
    Marshall-Gradisnik, Sonya M.
    Johnston, Samantha
    Brenu, Ekua
    Nguyen, Thao
    Passmore, Rachel
    Wong, Naomi CW.
    Hawthorn, Ally M.
    Year published
    2014
    Metadata
    Show full item record
    Abstract
    Aims Chronic Fatigue Syndrome (CFS) and Multiple Sclerosis (MS) are both disorders with severe neuroimmune symptoms, including cognitive impairment, immune dysfunction and abnormal cytokine expression. The purpose of this study was to assess the T helper (Th) 1, Th2 and Th17 cytokine profiles of CFS and MS patients. Methods This study measured the cytokine profiles of CFS patients (n = 16; mean age 49.88, SD 9.542), MS patients (n = 16; mean age 52.75, SD 12.809) and healthy controls (n = 16; mean age 50.06, SD 11.846). The diagnostic selection method used to identify CFS patients was the International Consensus Criteria. ...
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    Aims Chronic Fatigue Syndrome (CFS) and Multiple Sclerosis (MS) are both disorders with severe neuroimmune symptoms, including cognitive impairment, immune dysfunction and abnormal cytokine expression. The purpose of this study was to assess the T helper (Th) 1, Th2 and Th17 cytokine profiles of CFS and MS patients. Methods This study measured the cytokine profiles of CFS patients (n = 16; mean age 49.88, SD 9.542), MS patients (n = 16; mean age 52.75, SD 12.809) and healthy controls (n = 16; mean age 50.06, SD 11.846). The diagnostic selection method used to identify CFS patients was the International Consensus Criteria. Cytokines were measured from serum using a Bio-Plex Pro™ kit for Th1 (IFN-γ, TNF-α), Th2 (IL-4, IL-6, IL-10, IL-13) and Th17 (IL-17) cell cytokines. Results When the three groups were compared, it was found that TNF-α (p = 0.011, p = 0.012), IL-4 (p = 0.000, p = 0.000), IL-6 (p = 0.039, p = 0.031), IL-13 (p = 0.000, p = 0.000) and IL-17 (p = 0.004, p = 0.038) were all significantly higher in MS patients compared with CFS patients and controls respectively. However, in the MS patients and CFS patients, serum levels of IL-13 and IFN-γ were significantly higher (p ⩽ 0.001) compared with the controls. IFN-γ was significantly different between MS and CFS (p = 0.001), with MS exhibiting higher IFN-γ serum levels. Conclusion Cytokines patterns supported both Th1 and Th2 cytokine profiles in CFS and MS. Similarities in the cytokine profiles of MS and CFS, combined with the already acknowledged similarities in immune cell function and symptoms, suggests a neuroimmune pathology for CFS with parallels to that of MS. Additional studies into the cytokine profiles of both CFS and MS should be conducted, with larger sample sizes, to further expand the understanding of the pathologies of both disorders.
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    Conference Title
    CYTOKINE
    Volume
    70
    Issue
    1
    Publisher URI
    http://icis2014.aisnet.org/
    DOI
    https://doi.org/10.1016/j.cyto.2014.07.206
    Subject
    Medical and Health Sciences not elsewhere classified
    Immunology
    Biochemistry and Cell Biology
    Genetics
    Publication URI
    http://hdl.handle.net/10072/67904
    Collection
    • Conference outputs

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