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  • Alterations in innate and adaptive immune cells in moderate versus severely affected Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

    Author(s)
    Hardcastle, Sharni Lee
    Brenu, Ekua
    Johnston, Samantha
    Nguyen, Thao
    Huth, Teilah Kathryn
    Kaur, M.
    Ramos, Sandra Bahia
    Salajegheh, Ali
    Broadley, Simon
    Staines, Don
    Marshall-Gradisnik, Sonya
    Griffith University Author(s)
    Staines, Don R.
    Broadley, Simon
    Ariana, Armin S.
    Hardcastle, Sharni L.
    Huth, Teilah K.
    Ramos, Sandra B.
    Marshall-Gradisnik, Sonya M.
    Johnston, Samantha
    Brenu, Ekua
    Nguyen, Thao
    Year published
    2014
    Metadata
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    Abstract
    Objective: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is a disabling illness, characterised by persistent, debilitating fatigue and a multitude of symptoms. Immunological alterations are prominent in CFS/ME cases, however little is known about the relationship between CFS/ME severity and the extent of immunological dysfunction. The purpose of this study was to assess innate and adaptive immune cell phenotypes and function of two groups of CFS/ME patients, bedridden (severe) and mobile (moderate). Methods: CFS/ME participants were defined using the Centres for Disease Prevention and Control (1994 CDC) Criteria ...
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    Objective: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is a disabling illness, characterised by persistent, debilitating fatigue and a multitude of symptoms. Immunological alterations are prominent in CFS/ME cases, however little is known about the relationship between CFS/ME severity and the extent of immunological dysfunction. The purpose of this study was to assess innate and adaptive immune cell phenotypes and function of two groups of CFS/ME patients, bedridden (severe) and mobile (moderate). Methods: CFS/ME participants were defined using the Centres for Disease Prevention and Control (1994 CDC) Criteria for CFS/ME. Participants were grouped into healthy controls (n= 22, age = 40.14 + 2.38), moderate/mobile (n = 23; age = 42.52 + 2.63) and severe/bedridden (n=18; age = 39.56 + 1.51) CFS/ME patients. Flow cytometric protocols were used to examine neutrophil, monocyte, dendritic cells (DCs), iNKT, Treg, B, γδ and CD8+ T cell phenotypes, NK cytotoxic activity and receptors. Results: The present data found that CFS/ME patients demonstrated significant decreases in NK cytotoxic activity, transitional and regulatory B cells, γδ1 T cells, KIR2DL1/DS1, CD94+ and KIR2DL2/L3. Significant increases in CD56-CD16+NKs, CD56dimCD16- and CD56brightCD16-/dim NKs, DCs, iNKT phenotypes, memory and naive B cells were also shown in CFS/ME participants. Severe CFS/ME patients demonstrated increased CD14-CD16+ DCs, memory and naïve B cells, total iNKT, iNKT cell and NK phenotypes compared to moderate CFS/ME patients. Conclusion: This study was the first to determine alterations in NK, iNKT, B, DC and γδ T cell phenotypes in both moderate and severe CFS/ME patients. Immunological alterations are present in innate and adaptive immune cells and sometimes, immune deregulation appears worse in CFS/ME patients with more severe symptoms. It may be appropriate for CFS/ME patient severity subgroups to be distinguished in both clinical and research settings to extricate further immunological pathologies that may not have been previously reported.
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    Conference Title
    Alterations in innate and adaptive immune cells in moderate versus severely affected Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
    Publisher URI
    http://studentresearchsymposium.com/about.php
    Subject
    Cellular Immunology
    Publication URI
    http://hdl.handle.net/10072/67938
    Collection
    • Conference outputs

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