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  • Immune cells in severe and moderate Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

    Author(s)
    Hardcastle, Sharni Lee
    Brenu, Ekua
    Johnston, Samantha
    Huth, Teilah Kathryn
    Nguyen, Thao
    Ramos, Sandra Bahia
    Staines, Don
    Marshall-Gradisnik, Sonya
    Griffith University Author(s)
    Staines, Don R.
    Hardcastle, Sharni L.
    Huth, Teilah K.
    Ramos, Sandra B.
    Marshall-Gradisnik, Sonya M.
    Johnston, Samantha
    Brenu, Ekua
    Nguyen, Thao
    Year published
    2014
    Metadata
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    Abstract
    Objectives: Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME) is a disabling illness characterised by persistent fatigue and a multitude of symptoms. CFS/ME symptom presentation varies greatly among patients, suggesting potential severity subgroups within the illness. Studies have also only consistently focused only on CFS/ME patients with moderate severity. Therefore this study investigated CFS/ME severity subgroups in CFS/ME while assessing a wide range of innate (NK, neutrophil, monocyte and DC’s) and adaptive (iNKT and B cells) immune cells based on phenotypes and functioning to determine the extent of ...
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    Objectives: Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME) is a disabling illness characterised by persistent fatigue and a multitude of symptoms. CFS/ME symptom presentation varies greatly among patients, suggesting potential severity subgroups within the illness. Studies have also only consistently focused only on CFS/ME patients with moderate severity. Therefore this study investigated CFS/ME severity subgroups in CFS/ME while assessing a wide range of innate (NK, neutrophil, monocyte and DC’s) and adaptive (iNKT and B cells) immune cells based on phenotypes and functioning to determine the extent of immunological dysfunction. Methods: Participants were grouped into 22 non-fatigued controls (age = 40.14 + 2.38), 23 moderate (age = 42.52 + 2.63) and 18 severely (age = 39.56 + 1.51) affected CFS/ME patients using a number of severity scales. Results: Results confirmed significant decreases in NK cytotoxic activity and alterations in NK, DCs, iNKT and B cell phenotypes. Conclusion: This is the first to determine alterations in DC, iNKT and B cell phenotypes in severe CFS/ME patients. This supports the notion that immunological biomarkers are necessary in CFS/ME and that severity subgroups should be assessed in both clinical and research settings.
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    Conference Title
    Immune cells in severe and moderate Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.
    Publisher URI
    http://phoenixrising.me/archives/21738
    Subject
    Cellular Immunology
    Publication URI
    http://hdl.handle.net/10072/67992
    Collection
    • Conference outputs

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