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dc.contributor.authorBrigelius-Flohe, R
dc.contributor.authorKelly, FJ
dc.contributor.authorSalonen, JT
dc.contributor.authorNeuzil, J
dc.contributor.authorZingg, JM
dc.contributor.authorAzzi, A
dc.date.accessioned2017-05-03T16:35:07Z
dc.date.available2017-05-03T16:35:07Z
dc.date.issued2002
dc.identifier.issn0002-9165
dc.identifier.urihttp://hdl.handle.net/10072/6806
dc.description.abstractVitamin E is indispensible for reproduction in female rats. In humans, vitamin E deficiency primarily causes neurologic dysfunctions, but the underlying molecular mechanisms are unclear. Because of its antioxidative properties, vitamin E is believed to help prevent diseases associated with oxidative stress, such as cardiovascular disease, cancer, chronic inflammation, and neurologic disorders. However, recent clinical trials undertaken to prove this hypothesis failed to verify a consistent benefit. Given these findings, a group of European scientists met to analyze the most recent knowledge of vitamin E function and metabolism. An overview of their discussions is presented in this article, which includes considerations of the mechanisms of absorption, distribution, and metabolism of different forms of vitamin E, including the {alpha}-tocopherol transfer protein and {alpha}-tocopherol-associated proteins; the mechanism of tocopherol side-chain degradation and its putative interaction with drug metabolism; the usefulness of tocopherol metabolites as biomarkers; and the novel mechanisms of the antiatherosclerotic and anticarcinogenic properties of vitamin E, which involve modulation of cellular signaling, transcriptional regulation, and induction of apoptosis. Clinical trials were analyzed on the basis of the selection of subjects, the stage of disease, and the mode of intake, dosage, and chemical form of vitamin E. In addition, the scarce knowledge on the role of vitamin E in reproduction was summarized. In conclusion, the scientists agreed that the functions of vitamin E were underestimated if one considered only its antioxidative properties. Future research on this essential vitamin should focus on what makes it essential for humans, why the body apparently utilizes {alpha}-tocopherol preferentially, and what functions other forms of vitamin E have.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Society for Nutrition
dc.publisher.placeUnited States
dc.publisher.urihttp://www.ajcn.org/cgi/content/abstract/76/4/703
dc.relation.ispartofpagefrom703
dc.relation.ispartofpageto716
dc.relation.ispartofjournalAmerican Journal of Clinical Nutrition
dc.relation.ispartofvolume76
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode40
dc.subject.fieldofresearchcode32
dc.titleThe European perspective on vitamin E: current knowledge and future research
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
gro.date.issued2015-02-04T04:25:20Z
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri


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