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  • Imidazo[1,2-b]pyridazines. XVII. Synthesis and central nervous system activity of some 6-(alkylthio and chloro)-3-(methoxy, unsubstituted and benzamidomethyl)-2-arylimidazo[1,2-b]pyridazines containing methoxy, methylenedioxy and methyl substituents.

    Author(s)
    BARLIN, GB
    DAVIES, LP
    DAVIS, RA
    HARRISON, PW
    Griffith University Author(s)
    Davis, Rohan A.
    Year published
    1994
    Metadata
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    Abstract
    Syntheses are reported for 6-(methylthio, ethylthio, propylthio, substituted benzylthio and chloro)-3-(methoxy, unsubstituted and benzamidomethyl)-2-arylimidazo[1,2-b]pyridazines contg. methoxy, methylenedioxy and Me groups attached to Ph substituents. In tests of the ability of these compds. to displace [3H]diazepam from rat brain membranes, 3-methoxy-6-(3',4'-methylenedioxybenzylthio)-2-(3'',4''-methylenedioxyphenyl)imidazo[1,2-b]pyridazine (IC50 1 nM) bound most strongly; methylenedioxy groups were beneficial to activity whereas polymethoxy or di-Me substituents were generally detrimental.Syntheses are reported for 6-(methylthio, ethylthio, propylthio, substituted benzylthio and chloro)-3-(methoxy, unsubstituted and benzamidomethyl)-2-arylimidazo[1,2-b]pyridazines contg. methoxy, methylenedioxy and Me groups attached to Ph substituents. In tests of the ability of these compds. to displace [3H]diazepam from rat brain membranes, 3-methoxy-6-(3',4'-methylenedioxybenzylthio)-2-(3'',4''-methylenedioxyphenyl)imidazo[1,2-b]pyridazine (IC50 1 nM) bound most strongly; methylenedioxy groups were beneficial to activity whereas polymethoxy or di-Me substituents were generally detrimental.
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    Journal Title
    Australian Journal of Chemistry
    Volume
    47
    DOI
    https://doi.org/10.1071/CH9942001
    Subject
    Chemical Sciences
    Publication URI
    http://hdl.handle.net/10072/68105
    Collection
    • Journal articles

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