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dc.contributor.authorBARLIN, GB
dc.contributor.authorDAVIES, LP
dc.contributor.authorDAVIS, RA
dc.contributor.authorHARRISON, PW
dc.date.accessioned2006-07-28
dc.date.accessioned2015-05-22T00:09:39Z
dc.date.accessioned2017-03-01T23:55:19Z
dc.date.available2015-05-22T00:09:39Z
dc.date.available2017-03-01T23:55:19Z
dc.date.issued1994
dc.identifier.issn0004-9425
dc.identifier.doi10.1071/CH9942001
dc.identifier.urihttp://hdl.handle.net/10072/68105
dc.description.abstractSyntheses are reported for 6-(methylthio, ethylthio, propylthio, substituted benzylthio and chloro)-3-(methoxy, unsubstituted and benzamidomethyl)-2-arylimidazo[1,2-b]pyridazines contg. methoxy, methylenedioxy and Me groups attached to Ph substituents. In tests of the ability of these compds. to displace [3H]diazepam from rat brain membranes, 3-methoxy-6-(3',4'-methylenedioxybenzylthio)-2-(3'',4''-methylenedioxyphenyl)imidazo[1,2-b]pyridazine (IC50 1 nM) bound most strongly; methylenedioxy groups were beneficial to activity whereas polymethoxy or di-Me substituents were generally detrimental.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherCSIRO Publishing
dc.publisher.placeCollingwood, Vic.
dc.relation.ispartofpagefrom2001
dc.relation.ispartofpageto2002
dc.relation.ispartofjournalAustralian Journal of Chemistry
dc.relation.ispartofvolume47
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchcode03
dc.titleImidazo[1,2-b]pyridazines. XVII. Synthesis and central nervous system activity of some 6-(alkylthio and chloro)-3-(methoxy, unsubstituted and benzamidomethyl)-2-arylimidazo[1,2-b]pyridazines containing methoxy, methylenedioxy and methyl substituents.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyEskitis, Inst Cell&Molecular Therapies
gro.hasfulltextNo Full Text
gro.griffith.authorDavis, Rohan A.


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