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  • Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 1 Historical and established therapies

    Author(s)
    Broadley, Simon A
    Barnett, Michael H
    Boggild, Mike
    Brew, Bruce J
    Butzkueven, Helmut
    Heard, Robert
    Hodgkinson, Suzanne
    Kermode, Allan GI
    Lechner-Scott, Jeannette
    Macdonell, Richard AL
    Marriott, Mark
    Mason, Deborah F
    Parratt, John
    Reddel, Stephen W
    Shaw, Cameron P
    Slee, Mark
    Spies, Judith
    Taylor, Bruce V
    Carroll, William M
    Kilpatrick, Trevor J
    King, John
    McCombe, Pamela A
    Pollard, John D
    Willoughby, Ernest
    Griffith University Author(s)
    Broadley, Simon
    Butzkueven, Helmut
    Year published
    2014
    Metadata
    Show full item record
    Abstract
    Multiple sclerosis (MS) is a potentially life-changing immune mediated disease of the central nervous system. Until recently, treatment has been largely confined to acute treatment of relapses, symptomatic therapies and rehabilitation. Through persistent efforts of dedicated physicians and scientists around the globe for 160 years, a number of therapies that have an impact on the long term outcome of the disease have emerged over the past 20 years. In this three part series we review the practicalities, benefits and potential hazards of each of the currently available and emerging treatment options for MS. We pay particular ...
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    Multiple sclerosis (MS) is a potentially life-changing immune mediated disease of the central nervous system. Until recently, treatment has been largely confined to acute treatment of relapses, symptomatic therapies and rehabilitation. Through persistent efforts of dedicated physicians and scientists around the globe for 160 years, a number of therapies that have an impact on the long term outcome of the disease have emerged over the past 20 years. In this three part series we review the practicalities, benefits and potential hazards of each of the currently available and emerging treatment options for MS. We pay particular attention to ways of abrogating the risks of these therapies and provide advice on the most appropriate indications for using individual therapies. In Part 1 we review the history of the development of MS therapies and its connection with the underlying immunobiology of the disease. The established therapies for MS are reviewed in detail and their current availability and indications in Australia and New Zealand are summarised. We examine the evidence to support their use in the treatment of MS.
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    Journal Title
    Journal of Clinical Neuroscience
    Volume
    21
    Issue
    11
    DOI
    https://doi.org/10.1016/j.jocn.2014.01.016
    Subject
    Clinical sciences
    Neurosciences
    Publication URI
    http://hdl.handle.net/10072/68953
    Collection
    • Journal articles

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