Bronchiectasis: the arrival of better evidence
Author(s)
Goyal, V
Grimwood, K
Chang, AB
Griffith University Author(s)
Year published
2014
Metadata
Show full item recordAbstract
Bronchiectasis unrelated to cystic fibrosis is increasingly recognised as a major contributor to respiratory morbidity and mortality in children and adults living in countries of all income levels.1,2 Despite its importance, bronchiectasis has attracted little research. As a result, the management of bronchiectasis is often extrapolated from research on cystic fibrosis.1,2 However, this extrapolation might have unintended consequences. For example, recombinant human DNase, a mucolytic agent used successfully in cystic fibrosis, leads instead to increased exacerbations and hospital admissions, and accelerated pulmonary decline ...
View more >Bronchiectasis unrelated to cystic fibrosis is increasingly recognised as a major contributor to respiratory morbidity and mortality in children and adults living in countries of all income levels.1,2 Despite its importance, bronchiectasis has attracted little research. As a result, the management of bronchiectasis is often extrapolated from research on cystic fibrosis.1,2 However, this extrapolation might have unintended consequences. For example, recombinant human DNase, a mucolytic agent used successfully in cystic fibrosis, leads instead to increased exacerbations and hospital admissions, and accelerated pulmonary decline in adult patients with bronchiectasis.
View less >
View more >Bronchiectasis unrelated to cystic fibrosis is increasingly recognised as a major contributor to respiratory morbidity and mortality in children and adults living in countries of all income levels.1,2 Despite its importance, bronchiectasis has attracted little research. As a result, the management of bronchiectasis is often extrapolated from research on cystic fibrosis.1,2 However, this extrapolation might have unintended consequences. For example, recombinant human DNase, a mucolytic agent used successfully in cystic fibrosis, leads instead to increased exacerbations and hospital admissions, and accelerated pulmonary decline in adult patients with bronchiectasis.
View less >
Journal Title
The Lancet Respiratory Medicine
Volume
2
Issue
1
Subject
Clinical sciences
Other health sciences