Rhodium(II)-catalyzed intramolecular C-H insertion α- to oxygen: reactivity, selectivity and applications to natural product synthesis
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The selective functionalisation of C-H bonds is a powerful strategy for the construction of organic molecules and the Rh(II)-catalysed C-H insertion reaction is a particularly robust and useful tool for this purpose. This review discusses the insertion of Rh(II) carbenes into C-H bonds that are activated by a-oxygen substituents, focusing on the trends that have been observed in reactivity and selectivity, and the applications of this reaction to the total synthesis of complex natural products.
Organic & Biomolecular Chemistry
© 2015 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
Organic Chemical Synthesis