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dc.contributor.authorKhandaker, Gulam
dc.contributor.authorZurynski, Yvonne
dc.contributor.authorRidley, Greta
dc.contributor.authorButtery, Jim
dc.contributor.authorMarshall, Helen
dc.contributor.authorRichmond, Peter C.
dc.contributor.authorRoyle, Jenny
dc.contributor.authorGold, Michael
dc.contributor.authorWalls, Tony
dc.contributor.authorWhitehead, Bruce
dc.contributor.authorMcIntyre, Peter
dc.contributor.authorWood, Nicholas
dc.contributor.authorBooy, Robert
dc.contributor.authorElliott, Elizabeth
dc.date.accessioned2017-05-03T16:13:40Z
dc.date.available2017-05-03T16:13:40Z
dc.date.issued2014
dc.identifier.issn1750-2640
dc.identifier.doi10.1111/irv.12286
dc.identifier.urihttp://hdl.handle.net/10072/69281
dc.description.abstractBackground There are few large-scale, prospective studies of influenza A(H1N1)pdm09 in children that identify predictors of adverse outcomes. Objectives We aimed to examine clinical epidemiology and predictors for adverse outcomes in children hospitalised with influenza A(H1N1)pdm09 in Australia. Methods Active hospital surveillance in six tertiary paediatric referral centres (June-September, 2009). All children aged <15 years admitted with laboratory-confirmed influenza A(H1N1)pdm09 were studied. Results Of 601 children admitted with laboratory-confirmed influenza, 506 (84粥) had influenza A(H1N1)pdm09. Half (51簥) of children with influenza A(H1N1)pdm09 were previously healthy. Hospital stay was longer in children with pre-existing condition (mean 6繠versus 4繠days; P = 0簲) as was paediatric intensive care unit (PICU) stay (7簠versus 2糠days; P = 0簰5). Rapid diagnosis decreased both antibiotic use and length of hospital and PICU stay. Fifty (9繥) children were admitted to a PICU, 30 (5繥) required mechanical ventilation and 5 (0繥) died. Laboratory-proven bacterial co-infection and chronic lung disease were significant independent predictors of PICU admission (OR 6縹, 95% CI 3籵-15簶 and OR 3絸, 95% CI 1紱-9簷, respectively) and requirement for ventilation (OR 5綱, 95% CI 2粭14粸 and OR 5籸, 95% CI 1縭14縶, respectively). Chronic neurological disease was a predictor of admission to PICU (OR 2糰, 95% CI 1籴-4綱). Conclusions During the 2009 pandemic, influenza was a major cause of hospitalisation in tertiary paediatric hospitals. Co-infection and underlying chronic disease increased risk of PICU admission and/or ventilation. Half the children admitted were previously healthy, supporting a role for universal influenza vaccination in children.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent307745 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom636
dc.relation.ispartofpageto645
dc.relation.ispartofissue6
dc.relation.ispartofjournalInfluenza and Other Respiratory Viruses
dc.relation.ispartofvolume8
dc.rights.retentionY
dc.subject.fieldofresearchInfectious Diseases
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode110309
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1117
dc.titleClinical epidemiology and predictors of outcome in children hospitalised with influenza A(H1N1)pdm09 in 2009: a prospective national study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2014 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorRidley, Greta


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