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  • A systematic review and meta-analysis of cohort studies of echocardiographic findings in OSA children after adenotonsilectomy

    Author(s)
    Theresa Weber, Silke Anna
    Carvalho, Raíssa Pierri
    Ridley, Greta
    Williams, Katrina
    Dib, Regina
    Griffith University Author(s)
    Ridley, Greta
    Year published
    2014
    Metadata
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    Abstract
    Context: There is evidence that OSA in children can be associated with acute and chronic effects on the cardiovascular system due to repetitive episodes of apnea and hypoxemia. Objective: To assess whether there is an association between OSA and echocardiographic findings in children and whether that association persists after adenotonsillectomy. Data sources: A literature search was conducted based on PUBMED, EMBASE and LILACS. Study selection: Children with OSA and children who did not have OSA, who were aged =12 years. Data extraction: Two reviewers extracted data independently; the risk of bias was assessed by ...
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    Context: There is evidence that OSA in children can be associated with acute and chronic effects on the cardiovascular system due to repetitive episodes of apnea and hypoxemia. Objective: To assess whether there is an association between OSA and echocardiographic findings in children and whether that association persists after adenotonsillectomy. Data sources: A literature search was conducted based on PUBMED, EMBASE and LILACS. Study selection: Children with OSA and children who did not have OSA, who were aged =12 years. Data extraction: Two reviewers extracted data independently; the risk of bias was assessed by examining the selected sample, the recruitment method, completeness of follow up, and blinding. Results: Seven studies met all the inclusion criteria and methodological requirements. There was a significant difference with elevated mean pulmonary arterial pressure levels in OSA participants compared to those without OSA at preoperative assessment [mean difference (MD) 8.67; confidential interval (CI) 95% 6.09, 11.25]. OSA participants showed a statistically significant increased interventricular septum (IVS) thickness (mm) [MD 0.60; CI 95% 0.09, 1.11]; and right ventricular (RV) dimension (cm/m) [MD 0.19; CI 95% 0.10, 0.28]. There was also a significant increase in right ventricular (RV) dimension (cm/m) [MD 0.10; CI 95% 0.05, 0.14] in OSA children. Conclusion: There is moderate quality evidence regarding possible association between OSA and right heart repercussions. More prognosis studies are needed, to allow the combination of results in a meta-analysis.
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    Journal Title
    International Journal of Pediatric Otorhinolaryngology
    Volume
    78
    Issue
    10
    DOI
    https://doi.org/10.1016/j.ijporl.2014.07.021
    Subject
    Endocrinology
    Clinical Sciences
    Paediatrics and Reproductive Medicine
    Publication URI
    http://hdl.handle.net/10072/69282
    Collection
    • Journal articles

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