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dc.contributor.authorLevrier, Claire
dc.contributor.authorSadowski, Martin C
dc.contributor.authorNelson, Colleen C
dc.contributor.authorHealy, Peter C
dc.contributor.authorDavis, Rohan A
dc.date.accessioned2017-10-30T12:30:56Z
dc.date.available2017-10-30T12:30:56Z
dc.date.issued2015
dc.identifier.issn0163-3864
dc.identifier.doi10.1021/np500740f
dc.identifier.urihttp://hdl.handle.net/10072/69325
dc.description.abstractEight new dihydro-߭agarofurans, denhaminols A-H (1-8), were isolated from the leaves of the Australian rainforest tree Denhamia celastroides. The chemical structures of 1-8 were elucidated following analysis of 1D/2D NMR and MS data. The absolute configuration of denhaminol A (1) was determined by single-crystal X-ray crystallography. All compounds were evaluated for cytotoxic activity against the human prostate cancer cell line LNCaP, using live-cell imaging and metabolic assays. Denhaminols A (1) and G (7) were also tested for their effects on the lipid content of LNCaP cells. This is the first report of secondary metabolites from D. celastroides.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom111
dc.relation.ispartofpageto119
dc.relation.ispartofissue1
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume78
dc.rights.retentionN
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchBiologically active molecules
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchTraditional, complementary and integrative medicine
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode340401
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode4208
dc.titleDenhaminols A−H, Dihydro-β-agarofurans from the Endemic Australian Rainforest Plant Denhamia celastroides
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.rights.copyright© 2015 American Chemical Society and American Society of Pharmacognosy. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
gro.hasfulltextFull Text
gro.griffith.authorHealy, Peter C.
gro.griffith.authorDavis, Rohan A.


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